From [this](http://stackoverflow.com/questions/17979327/drop-rows-with-multiple-keys-in-pandas/17979614?noredirect=1#comment26286280_17979614) SO question. The user had two dataframes and wanted to use the second as the values argument to `isin`. We'd need to think about how to handle the other index. In this case the user only cared about the columns, not the index labels. Previous issues/PRs: #4258 and #4211