diff --git a/.github/workflows/build-stm.yml b/.github/workflows/build-stm.yml
index fdb46f06..d26823bf 100644
--- a/.github/workflows/build-stm.yml
+++ b/.github/workflows/build-stm.yml
@@ -28,6 +28,9 @@ jobs:
         with:
           python-version: 3.11
 
+      - name: Install uv
+        uses: astral-sh/setup-uv@v5
+
       - name: Install ${{ matrix.swift }}
         run: |
           wget -q https://download.swift.org/development/ubuntu2404/${{ matrix.swift }}/${{ matrix.swift }}-ubuntu24.04.tar.gz
@@ -39,6 +42,5 @@ jobs:
       - name: Build ${{ matrix.example }}
         working-directory: ${{ matrix.example }}
         run: |
-          pip3 install -r ../Tools/requirements.txt
           export STM_BOARD=STM32F746G_DISCOVERY
           ./build-elf.sh
diff --git a/README.md b/README.md
index 63f325dd..c925ae52 100644
--- a/README.md
+++ b/README.md
@@ -19,14 +19,9 @@ Each example in this repository contains build and deployment instructions, howe
 	
   You can follow the [tutorial here](https://apple.github.io/swift-matter-examples/tutorials/swiftmatterexamples/setup-macos/) for instructions on installing and using nighly Swift toolchains.
 
-2. Install the Python3 dependencies listed in `requirements.txt`.
-
-  ```console
-  $ cd swift-embedded-examples
-  $ python3 -m venv .venv
-  $ source .venv/bin/activate
-  $ python3 -m pip install -r Tools/requirements.txt
-  ```
+2. Install [`uv`](https://github.com/astral-sh/uv) "an extremely fast Python package and project manager".
+
+  You can follow the [instructions here](https://docs.astral.sh/uv/getting-started/installation/) to install `uv`.
 
 ## Catalog of Examples
 
diff --git a/Tools/elf2hex.py b/Tools/elf2hex.py
index db0449fa..37d360e4 100755
--- a/Tools/elf2hex.py
+++ b/Tools/elf2hex.py
@@ -1,4 +1,10 @@
-#!/usr/bin/env -S python3 -u -tt
+#! /usr/bin/env -S uv run --script
+
+# /// script
+# dependencies = [
+#   "pyelftools==0.31",
+# ]
+# ///
 
 # This source file is part of the Swift open source project
 #
diff --git a/Tools/macho2bin.py b/Tools/macho2bin.py
index 6ba74b3c..842b4b2f 100755
--- a/Tools/macho2bin.py
+++ b/Tools/macho2bin.py
@@ -1,4 +1,10 @@
-#!/usr/bin/env python3 -u -tt
+#! /usr/bin/env -S uv run --script
+
+# /// script
+# dependencies = [
+#   "macholib==1.16.3",
+# ]
+# ///
 
 # This source file is part of the Swift open source project
 #
diff --git a/Tools/macho2uf2.py b/Tools/macho2uf2.py
index 5043b4a8..39acd6c3 100755
--- a/Tools/macho2uf2.py
+++ b/Tools/macho2uf2.py
@@ -1,4 +1,10 @@
-#!/usr/bin/env python3 -u -tt
+#! /usr/bin/env -S uv run --script
+
+# /// script
+# dependencies = [
+#   "macholib==1.16.3",
+# ]
+# ///
 
 # This source file is part of the Swift open source project
 #
diff --git a/Tools/requirements.txt b/Tools/requirements.txt
deleted file mode 100644
index c07854d6..00000000
--- a/Tools/requirements.txt
+++ /dev/null
@@ -1,2 +0,0 @@
-macholib==1.16.3
-pyelftools==0.31