diff --git a/variants/NUCLEO_L073RZ/variant.cpp b/variants/NUCLEO_L073RZ/variant.cpp
index 807677556c..e7ea41720e 100644
--- a/variants/NUCLEO_L073RZ/variant.cpp
+++ b/variants/NUCLEO_L073RZ/variant.cpp
@@ -122,14 +122,16 @@ WEAK void SystemClock_Config(void)
 
   RCC_OscInitTypeDef RCC_OscInitStruct;
   RCC_ClkInitTypeDef RCC_ClkInitStruct;
+  RCC_PeriphCLKInitTypeDef PeriphClkInit;
 
   /* Configure the main internal regulator output voltage */
   __HAL_PWR_VOLTAGESCALING_CONFIG(PWR_REGULATOR_VOLTAGE_SCALE1);
 
   /* Initializes the CPU, AHB and APB busses clocks */
-  RCC_OscInitStruct.OscillatorType = RCC_OSCILLATORTYPE_HSI;
+  RCC_OscInitStruct.OscillatorType = RCC_OSCILLATORTYPE_HSI | RCC_OSCILLATORTYPE_HSI48;
   RCC_OscInitStruct.HSIState = RCC_HSI_ON;
-  RCC_OscInitStruct.HSICalibrationValue = 16;
+  RCC_OscInitStruct.HSICalibrationValue = RCC_HSICALIBRATION_DEFAULT;
+  RCC_OscInitStruct.HSI48State = RCC_HSI48_ON;
   RCC_OscInitStruct.PLL.PLLState = RCC_PLL_ON;
   RCC_OscInitStruct.PLL.PLLSource = RCC_PLLSOURCE_HSI;
   RCC_OscInitStruct.PLL.PLLMUL = RCC_PLLMUL_4;
@@ -149,6 +151,12 @@ WEAK void SystemClock_Config(void)
   if (HAL_RCC_ClockConfig(&RCC_ClkInitStruct, FLASH_LATENCY_1) != HAL_OK) {
     _Error_Handler(__FILE__, __LINE__);
   }
+
+  PeriphClkInit.PeriphClockSelection = RCC_PERIPHCLK_USB;
+  PeriphClkInit.UsbClockSelection = RCC_USBCLKSOURCE_HSI48;
+  if (HAL_RCCEx_PeriphCLKConfig(&PeriphClkInit) != HAL_OK) {
+    _Error_Handler(__FILE__, __LINE__);
+  }
 }
 
 #ifdef __cplusplus