diff --git a/compiler/src/dotty/tools/dotc/transform/Splicer.scala b/compiler/src/dotty/tools/dotc/transform/Splicer.scala
index e950c125f43d..06162ef513fa 100644
--- a/compiler/src/dotty/tools/dotc/transform/Splicer.scala
+++ b/compiler/src/dotty/tools/dotc/transform/Splicer.scala
@@ -422,6 +422,10 @@ object Splicer {
         case _: NoSuchMethodException =>
           val msg = em"Could not find method ${clazz.getCanonicalName}.$name with parameters ($paramClasses%, %)"
           throw new StopInterpretation(msg, pos)
+        case MissingClassDefinedInCurrentRun(sym) if ctx.compilationUnit.isSuspendable =>
+            if (ctx.settings.XprintSuspension.value)
+              report.echo(i"suspension triggered by a dependency on $sym", pos)
+            ctx.compilationUnit.suspend() // this throws a SuspendException
       }
 
     private def stopIfRuntimeException[T](thunk: => T, method: JLRMethod): T =
diff --git a/tests/neg-macros/i13516/Persistance.scala b/tests/neg-macros/i13516/Persistance.scala
new file mode 100644
index 000000000000..dbabf59c7267
--- /dev/null
+++ b/tests/neg-macros/i13516/Persistance.scala
@@ -0,0 +1,5 @@
+import scala.quoted.*
+object Persistance:
+  inline def nameOf(inline e: Any): String = ${ nameOfImpl('e) }
+  private def nameOfImpl(e: Expr[Any])(using Quotes): Expr[String] = Expr("")
+  def foo(p: Versioned): Unit = {}
diff --git a/tests/neg-macros/i13516/Versioned.scala b/tests/neg-macros/i13516/Versioned.scala
new file mode 100644
index 000000000000..a7e10b2c8549
--- /dev/null
+++ b/tests/neg-macros/i13516/Versioned.scala
@@ -0,0 +1,3 @@
+// nopos-error
+class Versioned:
+  def serialize: String = Persistance.nameOf(0)