diff --git a/compiler/src/scala/quoted/runtime/impl/QuotesImpl.scala b/compiler/src/scala/quoted/runtime/impl/QuotesImpl.scala
index 9e6669fe9256..34a0cd99c3f1 100644
--- a/compiler/src/scala/quoted/runtime/impl/QuotesImpl.scala
+++ b/compiler/src/scala/quoted/runtime/impl/QuotesImpl.scala
@@ -2455,7 +2455,7 @@ class QuotesImpl private (using val ctx: Context) extends Quotes, QuoteUnpickler
           }
 
         def isDefinedInCurrentRun: Boolean =
-          self.topLevelClass.asClass.isDefinedInCurrentRun
+          self.exists && self.topLevelClass.asClass.isDefinedInCurrentRun
         def isLocalDummy: Boolean = self.denot.isLocalDummy
         def isRefinementClass: Boolean = self.denot.isRefinementClass
         def isAliasType: Boolean = self.denot.isAliasType
diff --git a/tests/pos-macros/i13095/Macro_1.scala b/tests/pos-macros/i13095/Macro_1.scala
new file mode 100644
index 000000000000..776d2a18533a
--- /dev/null
+++ b/tests/pos-macros/i13095/Macro_1.scala
@@ -0,0 +1,9 @@
+
+import scala.quoted.*
+
+inline def testMacro = ${ test }
+
+def test(using Quotes): Expr[Unit] =
+  import quotes.reflect.*
+  assert(!Symbol.noSymbol.isDefinedInCurrentRun)
+  '{}
diff --git a/tests/pos-macros/i13095/Test_2.scala b/tests/pos-macros/i13095/Test_2.scala
new file mode 100644
index 000000000000..b301473885ac
--- /dev/null
+++ b/tests/pos-macros/i13095/Test_2.scala
@@ -0,0 +1 @@
+def unitTest = testMacro