diff --git a/.circleci/config.yml b/.circleci/config.yml
index 2cd49d4d398..776b4d9ad44 100644
--- a/.circleci/config.yml
+++ b/.circleci/config.yml
@@ -6,7 +6,7 @@ orbs:
 jobs:
   tests:
     docker:
-      - image: 'cimg/python:3.8'
+      - image: 'cimg/python:3.10'
         environment:
           TOX_POSARGS: ''
       - image: 'docker.elastic.co/elasticsearch/elasticsearch:7.14.0'
@@ -19,12 +19,12 @@ jobs:
       - run: git submodule sync
       - run: git submodule update --init
       - run: pip install --user tox
-      - run: tox -e py38
+      - run: tox -e py310
       - codecov/upload
 
   tests-embedapi:
     docker:
-      - image: 'cimg/python:3.8'
+      - image: 'cimg/python:3.10'
     steps:
       - checkout
       - run: git submodule sync
@@ -34,7 +34,7 @@ jobs:
 
   checks:
     docker:
-      - image: 'cimg/python:3.8'
+      - image: 'cimg/python:3.10'
         environment:
           NODE_VERSION: 10.17.0
     steps:
diff --git a/dockerfiles/Dockerfile b/dockerfiles/Dockerfile
index 65c74e97298..e533c38490c 100644
--- a/dockerfiles/Dockerfile
+++ b/dockerfiles/Dockerfile
@@ -1,4 +1,4 @@
-FROM ubuntu:20.04
+FROM ubuntu:22.04
 
 ARG GITHUB_USER
 ARG GITHUB_TOKEN
@@ -24,21 +24,12 @@ RUN apt-get -y install \
         libmysqlclient-dev \
         libfreetype6 \
         libjpeg-dev \
+        postgresql-client \
         sqlite \
         netcat \
         telnet \
         lsb-release
 
-# https://www.postgresql.org/download/linux/ubuntu/
-# Use PostgreSQL client 12 from official PostgreSQL Ubuntu's repository to avoid this WARNING
-# WARNING: psql major version 10, server major version 12.
-# Some psql features might not work.
-# TODO: remove this when upgrading to Ubuntu 20.04 LTS
-RUN sh -c 'echo "deb http://apt.postgresql.org/pub/repos/apt $(lsb_release -cs)-pgdg main" > /etc/apt/sources.list.d/pgdg.list'
-RUN curl -s https://www.postgresql.org/media/keys/ACCC4CF8.asc | apt-key add -
-RUN apt-get -y update
-RUN apt-get -y install postgresql-client-12
-
 # Uncomment en_US.UTF-8 locale and generate it
 RUN sed -i -e 's/# en_US.UTF-8 UTF-8/en_US.UTF-8 UTF-8/' /etc/locale.gen && \
     locale-gen
diff --git a/docs/dev/install.rst b/docs/dev/install.rst
index 1151c81b5c3..6f1175c6c32 100644
--- a/docs/dev/install.rst
+++ b/docs/dev/install.rst
@@ -133,7 +133,7 @@ save some work while typing docker compose commands. This section explains these
 ``inv docker.test``
     Runs all the test suites inside the container.
 
-    * ``--arguments`` will pass arguments to Tox command (e.g. ``--arguments "-e py38 -- -k test_api"``)
+    * ``--arguments`` will pass arguments to Tox command (e.g. ``--arguments "-e py310 -- -k test_api"``)
 
 ``inv docker.pull``
     Downloads and tags all the Docker images required for builders.
diff --git a/docs/dev/tests.rst b/docs/dev/tests.rst
index ee24d019085..a789c7cd082 100644
--- a/docs/dev/tests.rst
+++ b/docs/dev/tests.rst
@@ -46,16 +46,16 @@ To target a specific environment:
 
 .. prompt:: bash
 
-   tox -e py38
+   tox -e py310
 
 The ``tox`` configuration has the following environments configured. You can
 target a single environment to limit the test suite:
 
-py38
-    Run our test suite using Python 3.8
+py310
+    Run our test suite using Python 3.10
 
-py38-debug
-    Same as ``py38``, but there are some useful debugging tools available in the environment.
+py310-debug
+    Same as ``py310``, but there are some useful debugging tools available in the environment.
 
 lint
     Run code linting using `Prospector`_. This currently runs `pylint`_,
diff --git a/tox.embedapi.ini b/tox.embedapi.ini
index 984331ccd49..f64a3a9172d 100644
--- a/tox.embedapi.ini
+++ b/tox.embedapi.ini
@@ -1,5 +1,6 @@
 [tox]
-envlist = sphinx-{18,20,21,22,23,24,30,31,32,33,34,35,40,41,42,latest}
+# NOTE: Sphinx 3.5 and 4.x < 4.2 fails with Python 3.10 because of a typing issue
+envlist = sphinx-{18,20,21,22,23,24,30,31,32,33,34,42,43,44,45,latest}
 
 [testenv]
 description = run test suite for the EmbedAPIv3
@@ -24,13 +25,14 @@ deps =
     sphinx-32: Sphinx~=3.2.0
     sphinx-33: Sphinx~=3.3.0
     sphinx-34: Sphinx~=3.4.0
-    sphinx-35: Sphinx~=3.5.0
-    sphinx-40: Sphinx~=4.0.0
-    sphinx-41: Sphinx~=4.1.0
     sphinx-42: Sphinx~=4.2.0
+    sphinx-43: Sphinx~=4.3.0
+    sphinx-44: Sphinx~=4.4.0
+    sphinx-45: Sphinx~=4.5.0
     sphinx-latest: Sphinx
     jinja2<3.1.0
 setenv =
     DJANGO_SETTINGS_MODULE=readthedocs.settings.test
+    VIRTUALENV_SETUPTOOLS=58.3.0
 changedir = {toxinidir}/readthedocs
 commands = pytest -m embed_api {posargs}
diff --git a/tox.ini b/tox.ini
index 7d113ccd662..d34f37c29d6 100644
--- a/tox.ini
+++ b/tox.ini
@@ -1,6 +1,6 @@
 [tox]
 minversion=2.9.0
-envlist = py38,lint,docs
+envlist = py310,lint,docs
 skipsdist = True
 
 [testenv]
@@ -11,12 +11,13 @@ setenv =
     LANG=en_US.UTF-8
     LC_ALL=en_US.UTF-8
     DJANGO_SETTINGS_SKIP_LOCAL=True
+    VIRTUALENV_SETUPTOOLS=58.3.0
 passenv = CI TRAVIS TRAVIS_* HOME
 deps =
   -r requirements/testing.txt
   debug: -r requirements/debug.txt
 basepython =
-    python3.8
+    python3.10
 commands =
     /bin/sh -c '\
         export DJANGO_SETTINGS_MODULE=readthedocs.settings.test; \