diff --git a/.circleci/config.yml b/.circleci/config.yml
index a413abbaf05..1a4560b5a33 100644
--- a/.circleci/config.yml
+++ b/.circleci/config.yml
@@ -26,7 +26,8 @@ jobs:
       - run: git submodule update --init
       - run: sudo apt update
       - run: sudo apt install -y rclone
-      - run: pip install --user tox
+      - run: pip install --user tox tox-uv
+      - run: tox --version
       - run: tox -e py312
       - codecov/upload
 
@@ -50,7 +51,8 @@ jobs:
       - run: git submodule update --init
       - run: sudo apt update
       - run: sudo apt install -y rclone
-      - run: pip install --user tox
+      - run: pip install --user tox tox-uv
+      - run: tox --version
       - run: tox -e ext-theme
 
   tests-embedapi:
@@ -60,7 +62,7 @@ jobs:
       - checkout
       - run: git submodule sync
       - run: git submodule update --init
-      - run: pip install --user 'tox<4'
+      - run: pip install --user tox tox-uv
       - run: tox --version
       - run: tox -c tox.embedapi.ini
 
@@ -81,7 +83,8 @@ jobs:
       - restore_cache:
           keys:
           - pre-commit-cache-{{ checksum "pre-commit-cache-key.txt" }}
-      - run: pip install --user tox
+      - run: pip install --user tox tox-uv
+      - run: tox --version
       - run: tox -e pre-commit
       - run: tox -e migrations
       - node/install:
diff --git a/requirements/docker.in b/requirements/docker.in
index 4d145275d69..de227ab6d62 100644
--- a/requirements/docker.in
+++ b/requirements/docker.in
@@ -4,6 +4,7 @@
 
 # run tests
 tox
+tox-uv
 
 # Used together with structlog to have nicer logs locally
 rich
diff --git a/requirements/docker.txt b/requirements/docker.txt
index afed55f6d5a..7c2279574ce 100644
--- a/requirements/docker.txt
+++ b/requirements/docker.txt
@@ -297,6 +297,7 @@ packaging==25.0
     #   gunicorn
     #   pyproject-api
     #   tox
+    #   tox-uv
 parso==0.8.4
     # via jedi
 pdbpp==0.11.6
@@ -447,6 +448,9 @@ toml==0.10.2
     #   bumpver
 tox==4.25.0
     # via -r requirements/docker.in
+    #   tox-uv
+tox-uv==1.16.1
+    # via -r requirements/docker.in
 traitlets==5.14.3
     # via
     #   ipython
@@ -495,6 +499,8 @@ urllib3==2.4.0
     #   requests
 user-agents==2.2.0
     # via -r requirements/pip.txt
+uv==0.5.8
+    # via tox-uv
 vine==5.1.0
     # via
     #   -r requirements/pip.txt
diff --git a/tox.embedapi.ini b/tox.embedapi.ini
index 95bd44eeda2..68f9be40e14 100644
--- a/tox.embedapi.ini
+++ b/tox.embedapi.ini
@@ -15,8 +15,8 @@ install_command =
     # Sphinx from `requirements/pip.txt` but from the `deps=` field.
     sh -c ' \
         cat {toxinidir}/requirements/testing.txt | grep -v "Sphinx" > {toxinidir}/requirements/embedapi.txt; \
-        pip install -r {toxinidir}/requirements/embedapi.txt; \
-        pip install $*;' -- {opts} {packages}
+        uv pip sync {toxinidir}/requirements/embedapi.txt; \
+        uv pip install $*;' -- {packages}
 deps =
     sphinx-45: Sphinx~=4.5.0
     sphinx-53: Sphinx~=5.3.0