diff --git a/.gitignore b/.gitignore
index 7dd9b771..bca72971 100644
--- a/.gitignore
+++ b/.gitignore
@@ -1,6 +1,7 @@
 # Byte-compiled / optimized / DLL files
 __pycache__/
 *.py[cod]
+*.mypy_cache
 
 # C extensions
 *.so
@@ -67,3 +68,6 @@ target/
 
 # generated by setuptools_scm
 pytest_asyncio/_version.py
+
+# JetBrains Run Configurations
+.run
diff --git a/pytest_asyncio/plugin.py b/pytest_asyncio/plugin.py
index 934fb91c..3116fce2 100644
--- a/pytest_asyncio/plugin.py
+++ b/pytest_asyncio/plugin.py
@@ -322,6 +322,7 @@ async def setup():
 
         def finalizer() -> None:
             """Yield again, to finalize."""
+            nonlocal event_loop
 
             async def async_finalizer() -> None:
                 try:
@@ -333,6 +334,9 @@ async def async_finalizer() -> None:
                     msg += "Yield only once."
                     raise ValueError(msg)
 
+            if event_loop.is_closed():
+                event_loop = asyncio.new_event_loop()
+                asyncio.set_event_loop(event_loop)
             event_loop.run_until_complete(async_finalizer())
 
         result = event_loop.run_until_complete(setup())