diff --git a/CHANGELOG.rst b/CHANGELOG.rst
index bb10c006..3e7994bb 100644
--- a/CHANGELOG.rst
+++ b/CHANGELOG.rst
@@ -2,6 +2,10 @@
 Changelog
 =========
 
+UNRELEASED
+=================
+- Removes `setup.py` since all relevant configuration is present `setup.cfg`. Users requiring an editable installation of pytest-asyncio need to use pip v21.1 or newer. `#283 <https://github.com/pytest-dev/pytest-asyncio/issues/283>`_
+
 0.18.3 (22-03-25)
 =================
 - Adds `pytest-trio <https://pypi.org/project/pytest-trio/>`_ to the test dependencies
diff --git a/setup.py b/setup.py
deleted file mode 100644
index 7f1a1763..00000000
--- a/setup.py
+++ /dev/null
@@ -1,4 +0,0 @@
-from setuptools import setup
-
-if __name__ == "__main__":
-    setup()