diff --git a/pymc_experimental/model_transform/conditioning.py b/pymc_experimental/model_transform/conditioning.py
index 49de9f8e5..c0b5a7b74 100644
--- a/pymc_experimental/model_transform/conditioning.py
+++ b/pymc_experimental/model_transform/conditioning.py
@@ -1,9 +1,11 @@
+import warnings
 from typing import Any, List, Mapping, Optional, Sequence, Union
 
 from pymc import Model
 from pymc.logprob.transforms import RVTransform
 from pymc.pytensorf import _replace_vars_in_graphs
 from pymc.util import get_transformed_name, get_untransformed_name
+from pytensor.graph import ancestors
 from pytensor.tensor import TensorVariable
 
 from pymc_experimental.model_transform.basic import (
@@ -199,7 +201,15 @@ def do(
         # Just a sanity check
         assert model_var in fgraph.variables
 
-        intervention.name = model_var.name
+        # If the intervention references the original variable we must give it a different name
+        if model_var in ancestors([intervention]):
+            intervention.name = f"do_{model_var.name}"
+            warnings.warn(
+                f"Intervention expression references the variable that is being intervened: {model_var.name}. "
+                f"Intervention will be given the name: {intervention.name}"
+            )
+        else:
+            intervention.name = model_var.name
         dims = extract_dims(model_var)
         # If there are any RVs in the graph we introduce the intervention as a deterministic
         if rvs_in_graph([intervention]):
diff --git a/pymc_experimental/tests/model_transform/test_conditioning.py b/pymc_experimental/tests/model_transform/test_conditioning.py
index 6e3261774..6fcc82405 100644
--- a/pymc_experimental/tests/model_transform/test_conditioning.py
+++ b/pymc_experimental/tests/model_transform/test_conditioning.py
@@ -222,6 +222,23 @@ def test_do_prune(prune):
         assert set(do_m.named_vars) == orig_named_vars
 
 
+def test_do_self_reference():
+    """Check we can replace a variable by an expression that refers to the same variable."""
+    with pm.Model() as m:
+        x = pm.Normal("x", 0, 1)
+
+    with pytest.warns(
+        UserWarning,
+        match="Intervention expression references the variable that is being intervened",
+    ):
+        new_m = do(m, {x: x + 100})
+
+    x = new_m["x"]
+    do_x = new_m["do_x"]
+    draw_x, draw_do_x = pm.draw([x, do_x], draws=5)
+    np.testing.assert_allclose(draw_x + 100, draw_do_x)
+
+
 def test_change_value_transforms():
     with pm.Model() as base_m:
         p = pm.Uniform("p", 0, 1, transform=None)