diff --git a/CHANGELOG.md b/CHANGELOG.md
index 6ce4580530..6e9a68fd8d 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -2,6 +2,11 @@
 All notable changes to this project will be documented in this file.
 This project adheres to [Semantic Versioning](http://semver.org/).
 
+## [6.0.1] - 2025-02-16
+
+### Fixed
+- Fix `TypeError` when using `orjson` to serialize `pandas.NA`.
+
 ## [6.0.0] - 2025-01-28
 
 ### Added
diff --git a/plotly/io/_json.py b/plotly/io/_json.py
index 15375632c7..b45191a07b 100644
--- a/plotly/io/_json.py
+++ b/plotly/io/_json.py
@@ -529,7 +529,7 @@ def clean_to_json_compatible(obj, **kwargs):
 
     # pandas
     if pd is not None:
-        if obj is pd.NaT:
+        if obj is pd.NaT or obj is pd.NA:
             return None
         elif isinstance(obj, (pd.Series, pd.DatetimeIndex)):
             if numpy_allowed and obj.dtype.kind in ("b", "i", "u", "f"):
diff --git a/tests/test_io/test_to_from_plotly_json.py b/tests/test_io/test_to_from_plotly_json.py
index 8022bd3b8e..1c0440b033 100644
--- a/tests/test_io/test_to_from_plotly_json.py
+++ b/tests/test_io/test_to_from_plotly_json.py
@@ -260,3 +260,9 @@ def test_sanitize_json(engine):
     for bad, good in replacements.items():
         assert bad not in fig_json
         assert good in fig_json
+
+
+@pytest.mark.parametrize("na_value", [np.nan, pd.NaT, pd.NA])
+def test_na_values(engine, na_value):
+    result = pio.to_json_plotly(na_value, engine=engine)
+    assert result == "null"