diff --git a/CHANGELOG.md b/CHANGELOG.md
index f17a4a7e178..346dd66aa81 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -6,7 +6,8 @@ This project adheres to [Semantic Versioning](http://semver.org/).
 
 ### Fixed
   - Fixed another compatibility issue with Pandas 2.0, just affecting `px.*(line_close=True)` [[#4190](https://github.com/plotly/plotly.py/pull/4190)]
-  - Added some rounding to the `make_subplots` function to handle situations where the user-input specs cause the domain to exceed 1 by small amounts https://github.com/plotly/plotly.py/pull/4153
+  - Added some rounding to the `make_subplots` function to handle situations where the user-input specs cause the domain to exceed 1 by small amounts [[#4153](https://github.com/plotly/plotly.py/pull/4153)]
+  - Sanitize JSON output to prevent an XSS vector when graphs are inserted directly into HTML [[#4196](https://github.com/plotly/plotly.py/pull/4196)]
 
 ## [5.14.1] - 2023-04-05
 
diff --git a/packages/python/plotly/plotly/io/_json.py b/packages/python/plotly/plotly/io/_json.py
index ae9935b1dda..26ea14e063e 100644
--- a/packages/python/plotly/plotly/io/_json.py
+++ b/packages/python/plotly/plotly/io/_json.py
@@ -57,6 +57,25 @@ def coerce_to_strict(const):
         return const
 
 
+_swap_json = (
+    ("<", "\\u003c"),
+    (">", "\\u003e"),
+    ("/", "\\u002f"),
+)
+_swap_orjson = _swap_json + (
+    ("\u2028", "\\u2028"),
+    ("\u2029", "\\u2029"),
+)
+
+
+def _safe(json_str, _swap):
+    out = json_str
+    for unsafe_char, safe_char in _swap:
+        if unsafe_char in out:
+            out = out.replace(unsafe_char, safe_char)
+    return out
+
+
 def to_json_plotly(plotly_object, pretty=False, engine=None):
     """
     Convert a plotly/Dash object to a JSON string representation
@@ -120,7 +139,9 @@ def to_json_plotly(plotly_object, pretty=False, engine=None):
 
         from _plotly_utils.utils import PlotlyJSONEncoder
 
-        return json.dumps(plotly_object, cls=PlotlyJSONEncoder, **opts)
+        return _safe(
+            json.dumps(plotly_object, cls=PlotlyJSONEncoder, **opts), _swap_json
+        )
     elif engine == "orjson":
         JsonConfig.validate_orjson()
         opts = orjson.OPT_NON_STR_KEYS | orjson.OPT_SERIALIZE_NUMPY
@@ -136,7 +157,9 @@ def to_json_plotly(plotly_object, pretty=False, engine=None):
 
         # Try without cleaning
         try:
-            return orjson.dumps(plotly_object, option=opts).decode("utf8")
+            return _safe(
+                orjson.dumps(plotly_object, option=opts).decode("utf8"), _swap_orjson
+            )
         except TypeError:
             pass
 
@@ -146,7 +169,7 @@ def to_json_plotly(plotly_object, pretty=False, engine=None):
             datetime_allowed=True,
             modules=modules,
         )
-        return orjson.dumps(cleaned, option=opts).decode("utf8")
+        return _safe(orjson.dumps(cleaned, option=opts).decode("utf8"), _swap_orjson)
 
 
 def to_json(fig, validate=True, pretty=False, remove_uids=True, engine=None):
diff --git a/packages/python/plotly/plotly/tests/test_io/test_to_from_plotly_json.py b/packages/python/plotly/plotly/tests/test_io/test_to_from_plotly_json.py
index e21b556c6b8..cdcd78a5a41 100644
--- a/packages/python/plotly/plotly/tests/test_io/test_to_from_plotly_json.py
+++ b/packages/python/plotly/plotly/tests/test_io/test_to_from_plotly_json.py
@@ -6,6 +6,7 @@
 import pandas as pd
 import json
 import datetime
+import re
 import sys
 from pytz import timezone
 from _plotly_utils.optional_imports import get_module
@@ -201,6 +202,14 @@ def to_str(v):
 
     array_str = to_json_test(dt_values)
     expected = build_test_dict_string(array_str)
+    if orjson:
+        # orjson always serializes datetime64 to ns, but json will return either
+        # full seconds or microseconds, if the rest is zeros.
+        # we don't care about any trailing zeros
+        trailing_zeros = re.compile(r'[.]?0+"')
+        result = trailing_zeros.sub('"', result)
+        expected = trailing_zeros.sub('"', expected)
+
     assert result == expected
     check_roundtrip(result, engine=engine, pretty=pretty)
 
@@ -221,3 +230,25 @@ def test_mixed_string_nonstring_key(engine, pretty):
     value = build_test_dict({0: 1, "a": 2})
     result = pio.to_json_plotly(value, engine=engine)
     check_roundtrip(result, engine=engine, pretty=pretty)
+
+
+def test_sanitize_json(engine):
+    layout = {"title": {"text": "</script>\u2028\u2029"}}
+    fig = go.Figure(layout=layout)
+    fig_json = pio.to_json_plotly(fig, engine=engine)
+    layout_2 = json.loads(fig_json)["layout"]
+    del layout_2["template"]
+
+    assert layout == layout_2
+
+    replacements = {
+        "<": "\\u003c",
+        ">": "\\u003e",
+        "/": "\\u002f",
+        "\u2028": "\\u2028",
+        "\u2029": "\\u2029",
+    }
+
+    for bad, good in replacements.items():
+        assert bad not in fig_json
+        assert good in fig_json
diff --git a/packages/python/plotly/test_requirements/requirements_37_optional.txt b/packages/python/plotly/test_requirements/requirements_37_optional.txt
index 3fb4185e9c9..224fbf7db8b 100644
--- a/packages/python/plotly/test_requirements/requirements_37_optional.txt
+++ b/packages/python/plotly/test_requirements/requirements_37_optional.txt
@@ -19,3 +19,4 @@ matplotlib==2.2.3
 scikit-image==0.14.4
 psutil==5.7.0
 kaleido
+orjson==3.8.12
diff --git a/packages/python/plotly/test_requirements/requirements_39_optional.txt b/packages/python/plotly/test_requirements/requirements_39_optional.txt
index 34b686ad024..eae8cd6d2ec 100644
--- a/packages/python/plotly/test_requirements/requirements_39_optional.txt
+++ b/packages/python/plotly/test_requirements/requirements_39_optional.txt
@@ -19,3 +19,4 @@ matplotlib==2.2.3
 scikit-image==0.18.1
 psutil==5.7.0
 kaleido
+orjson==3.8.12