diff --git a/pandas/conftest.py b/pandas/conftest.py
index f9c10a7758bd2..9db58c9a82dd3 100644
--- a/pandas/conftest.py
+++ b/pandas/conftest.py
@@ -706,6 +706,7 @@ def _create_mi_with_dt64tz_level():
     "string-python": Index(
         pd.array([f"pandas_{i}" for i in range(10)], dtype="string[python]")
     ),
+    "mixed-int-string": Index([0, "a", 1, "b", 2, "c"]),
 }
 if has_pyarrow:
     idx = Index(pd.array([f"pandas_{i}" for i in range(10)], dtype="string[pyarrow]"))
diff --git a/pandas/tests/base/test_misc.py b/pandas/tests/base/test_misc.py
index 7819b7b75f065..afbce74d4af77 100644
--- a/pandas/tests/base/test_misc.py
+++ b/pandas/tests/base/test_misc.py
@@ -160,6 +160,10 @@ def test_searchsorted(request, index_or_series_obj):
         mark = pytest.mark.xfail(reason="complex objects are not comparable")
         request.applymarker(mark)
 
+    elif len({type(x) for x in obj}) > 1 and isinstance(obj, Index):
+        mark = pytest.mark.xfail(reason="np.searchsorted doesn't work on mixed types")
+        request.applymarker(mark)
+
     max_obj = max(obj, default=0)
     index = np.searchsorted(obj, max_obj)
     assert 0 <= index <= len(obj)