diff --git a/.github/workflows/unit-tests.yml b/.github/workflows/unit-tests.yml
index 982877ee7f365..ddb6ecbe83126 100644
--- a/.github/workflows/unit-tests.yml
+++ b/.github/workflows/unit-tests.yml
@@ -391,6 +391,7 @@ jobs:
         env:
           PYTHON_GIL: 0
 
+  # NOTE: this job must be kept in sync with the Pyodide build job in wheels.yml
   emscripten:
     # Note: the Python version, Emscripten toolchain version are determined
     # by the Pyodide version. The appropriate versions can be found in the
diff --git a/.github/workflows/wheels.yml b/.github/workflows/wheels.yml
index f61ef550f74df..02100648b636a 100644
--- a/.github/workflows/wheels.yml
+++ b/.github/workflows/wheels.yml
@@ -100,6 +100,13 @@ jobs:
         - [windows-2022, win_amd64]
         # TODO: support PyPy?
         python: [["cp310", "3.10"], ["cp311", "3.11"], ["cp312", "3.12"]]
+
+        # Build Pyodide wheels and upload them to Anaconda.org
+        # NOTE: this job is similar to the one in unit-tests.yml except for the fact
+        # that it uses cibuildwheel instead of a standard Pyodide xbuildenv setup.
+        include:
+          - buildplat: [ubuntu-22.04, pyodide_wasm32]
+            python: ["cp312", "3.12"]
     env:
       IS_PUSH: ${{ github.event_name == 'push' && startsWith(github.ref, 'refs/tags/v') }}
       IS_SCHEDULE_DISPATCH: ${{ github.event_name == 'schedule' || github.event_name == 'workflow_dispatch' }}
@@ -146,6 +153,7 @@ jobs:
         env:
           CIBW_PRERELEASE_PYTHONS: True
           CIBW_BUILD: ${{ matrix.python[0] }}-${{ matrix.buildplat[1] }}
+          CIBW_PLATFORM: ${{ matrix.buildplat[1] == 'pyodide_wasm32' && 'pyodide' || 'auto' }}
 
       - name: Set up Python
         uses: mamba-org/setup-micromamba@v1
diff --git a/pandas/tests/test_common.py b/pandas/tests/test_common.py
index 7b93416600f8f..ca97af0d3eb32 100644
--- a/pandas/tests/test_common.py
+++ b/pandas/tests/test_common.py
@@ -7,6 +7,8 @@
 import numpy as np
 import pytest
 
+from pandas.compat import WASM
+
 import pandas as pd
 from pandas import Series
 import pandas._testing as tm
@@ -233,6 +235,7 @@ def test_temp_setattr(with_exception):
     assert ser.name == "first"
 
 
+@pytest.mark.skipif(WASM, reason="Can't start subprocesses in WASM")
 @pytest.mark.single_cpu
 def test_str_size():
     # GH#21758
diff --git a/pyproject.toml b/pyproject.toml
index 9156c73efbb35..47fd540d67ab2 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -177,6 +177,16 @@ test-command = ""
 select = "*-macosx*"
 environment = {CFLAGS="-g0"}
 
+[[tool.cibuildwheel.overrides]]
+select = "*pyodide*"
+test-requires = "pytest>=7.3.2 hypothesis>=6.46.1"
+# Pyodide repairs wheels on its own, using auditwheel-emscripten
+repair-wheel-command = ""
+test-command = """
+  PANDAS_CI='1' python -c 'import pandas as pd; \
+  pd.test(extra_args=["-m not clipboard and not single_cpu and not slow and not network and not db", "--no-strict-data-files"]);' \
+  """
+
 [tool.ruff]
 line-length = 88
 target-version = "py310"