diff --git a/pandas/core/internals/blocks.py b/pandas/core/internals/blocks.py
index 80c8a1e8ef5c7..bd19aed631659 100644
--- a/pandas/core/internals/blocks.py
+++ b/pandas/core/internals/blocks.py
@@ -115,7 +115,10 @@
     ensure_wrapped_if_datetimelike,
     extract_array,
 )
-from pandas.core.indexers import check_setitem_lengths
+from pandas.core.indexers import (
+    check_array_indexer,
+    check_setitem_lengths,
+)
 from pandas.core.indexes.base import get_values_for_csv
 
 if TYPE_CHECKING:
@@ -1661,6 +1664,8 @@ def setitem(self, indexer, value):
             # TODO(GH#45419): string[pyarrow] tests break if we transpose
             #  unconditionally
             values = values.T
+
+        check_array_indexer(values, indexer)
         check_setitem_lengths(indexer, value, values)
 
         try:
diff --git a/pandas/tests/extension/base/setitem.py b/pandas/tests/extension/base/setitem.py
index 3fb2fc09eaa79..4410b3d0441af 100644
--- a/pandas/tests/extension/base/setitem.py
+++ b/pandas/tests/extension/base/setitem.py
@@ -206,12 +206,9 @@ def test_setitem_integer_array(self, data, idx, box_in_series):
         "idx, box_in_series",
         [
             ([0, 1, 2, pd.NA], False),
-            pytest.param(
-                [0, 1, 2, pd.NA], True, marks=pytest.mark.xfail(reason="GH-31948")
-            ),
+            ([0, 1, 2, pd.NA], True),
             (pd.array([0, 1, 2, pd.NA], dtype="Int64"), False),
-            # TODO: change False to True?
-            (pd.array([0, 1, 2, pd.NA], dtype="Int64"), False),  # noqa: PT014
+            (pd.array([0, 1, 2, pd.NA], dtype="Int64"), True),
         ],
         ids=["list-False", "list-True", "integer-array-False", "integer-array-True"],
     )
@@ -225,7 +222,10 @@ def test_setitem_integer_with_missing_raises(self, data, idx, box_in_series):
 
         msg = "Cannot index with an integer indexer containing NA values"
         with pytest.raises(ValueError, match=msg):
-            arr[idx] = arr[0]
+            if type(arr) is pd.Series:
+                arr.iloc[idx] = arr.iloc[0]
+            else:
+                arr[idx] = arr[0]
 
     @pytest.mark.parametrize("as_callable", [True, False])
     @pytest.mark.parametrize("setter", ["loc", None])
diff --git a/pandas/tests/extension/json/test_json.py b/pandas/tests/extension/json/test_json.py
index 6ecbf2063f203..9dd9fe5977f04 100644
--- a/pandas/tests/extension/json/test_json.py
+++ b/pandas/tests/extension/json/test_json.py
@@ -342,15 +342,24 @@ def test_setitem_integer_array(self, data, idx, box_in_series, request):
             request.applymarker(mark)
         super().test_setitem_integer_array(data, idx, box_in_series)
 
-    @pytest.mark.xfail(reason="list indices must be integers or slices, not NAType")
     @pytest.mark.parametrize(
         "idx, box_in_series",
         [
-            ([0, 1, 2, pd.NA], False),
             pytest.param(
-                [0, 1, 2, pd.NA], True, marks=pytest.mark.xfail(reason="GH-31948")
+                [0, 1, 2, pd.NA],
+                False,
+                marks=pytest.mark.xfail(
+                    reason="Cannot index with an integer indexer containing NA values"
+                ),
+            ),
+            ([0, 1, 2, pd.NA], True),
+            pytest.param(
+                pd.array([0, 1, 2, pd.NA], dtype="Int64"),
+                False,
+                marks=pytest.mark.xfail(
+                    reason="Cannot index with an integer indexer containing NA values"
+                ),
             ),
-            (pd.array([0, 1, 2, pd.NA], dtype="Int64"), False),
             (pd.array([0, 1, 2, pd.NA], dtype="Int64"), True),
         ],
         ids=["list-False", "list-True", "integer-array-False", "integer-array-True"],