diff --git a/pandas/_libs/lib.pyi b/pandas/_libs/lib.pyi
index 15bd5a7379105..946cbb7dbf6f1 100644
--- a/pandas/_libs/lib.pyi
+++ b/pandas/_libs/lib.pyi
@@ -44,6 +44,7 @@ def is_iterator(obj: object) -> bool: ...
 def is_scalar(val: object) -> bool: ...
 def is_list_like(obj: object, allow_sets: bool = ...) -> bool: ...
 def is_pyarrow_array(obj: object) -> bool: ...
+def is_null_slice(obj: object) -> bool: ...
 def is_period(val: object) -> TypeGuard[Period]: ...
 def is_interval(val: object) -> TypeGuard[Interval]: ...
 def is_decimal(val: object) -> TypeGuard[Decimal]: ...
diff --git a/pandas/_libs/lib.pyx b/pandas/_libs/lib.pyx
index 0c0610f72044e..a9af158556f3e 100644
--- a/pandas/_libs/lib.pyx
+++ b/pandas/_libs/lib.pyx
@@ -29,6 +29,7 @@ from cpython.object cimport (
 )
 from cpython.ref cimport Py_INCREF
 from cpython.sequence cimport PySequence_Check
+from cpython.slice cimport PySlice_Unpack
 from cpython.tuple cimport (
     PyTuple_New,
     PyTuple_SET_ITEM,
@@ -71,6 +72,7 @@ cdef extern from "Python.h":
     # Note: importing extern-style allows us to declare these as nogil
     # functions, whereas `from cpython cimport` does not.
     bint PyObject_TypeCheck(object obj, PyTypeObject* type) nogil
+    cdef Py_ssize_t PY_SSIZE_T_MAX
 
 cdef extern from "numpy/arrayobject.h":
     # cython's numpy.dtype specification is incorrect, which leads to
@@ -1250,6 +1252,20 @@ def is_pyarrow_array(obj):
     return False
 
 
+def is_null_slice(obj):
+    cdef Py_ssize_t start, stop, step
+    if isinstance(obj, slice):
+        try:
+            PySlice_Unpack(obj, &start, &stop, &step)
+        except TypeError:
+            return False
+
+        if start == 0 and stop == PY_SSIZE_T_MAX and step == 1:
+            return True
+
+    return False
+
+
 _TYPE_MAP = {
     "categorical": "categorical",
     "category": "categorical",
diff --git a/pandas/core/common.py b/pandas/core/common.py
index 8fd8b10c6fc32..2b243ec21818d 100644
--- a/pandas/core/common.py
+++ b/pandas/core/common.py
@@ -307,12 +307,7 @@ def is_null_slice(obj) -> bool:
     """
     We have a null slice.
     """
-    return (
-        isinstance(obj, slice)
-        and obj.start is None
-        and obj.stop is None
-        and obj.step is None
-    )
+    return lib.is_null_slice(obj)
 
 
 def is_empty_slice(obj) -> bool: