diff --git a/doc/source/whatsnew/v2.2.0.rst b/doc/source/whatsnew/v2.2.0.rst
index a9522a09d73be..f03a091541d03 100644
--- a/doc/source/whatsnew/v2.2.0.rst
+++ b/doc/source/whatsnew/v2.2.0.rst
@@ -134,6 +134,7 @@ Deprecations
 - Deprecated allowing non-keyword arguments in :meth:`DataFrame.to_clipboard`. (:issue:`54229`)
 - Deprecated allowing non-keyword arguments in :meth:`DataFrame.to_csv` except ``path_or_buf``. (:issue:`54229`)
 - Deprecated allowing non-keyword arguments in :meth:`DataFrame.to_dict`. (:issue:`54229`)
+- Deprecated allowing non-keyword arguments in :meth:`DataFrame.to_gbq` except ``destination_table``. (:issue:`54229`)
 - Deprecated allowing non-keyword arguments in :meth:`DataFrame.to_hdf` except ``path_or_buf``. (:issue:`54229`)
 - Deprecated allowing non-keyword arguments in :meth:`DataFrame.to_html` except ``buf``. (:issue:`54229`)
 - Deprecated allowing non-keyword arguments in :meth:`DataFrame.to_json` except ``path_or_buf``. (:issue:`54229`)
diff --git a/pandas/core/frame.py b/pandas/core/frame.py
index c52f9cae78c91..e9d8ba6aab4a8 100644
--- a/pandas/core/frame.py
+++ b/pandas/core/frame.py
@@ -2048,6 +2048,9 @@ def to_dict(
 
         return to_dict(self, orient, into, index)
 
+    @deprecate_nonkeyword_arguments(
+        version="3.0", allowed_args=["self", "destination_table"], name="to_gbq"
+    )
     def to_gbq(
         self,
         destination_table: str,