diff --git a/pandas/tests/apply/test_series_apply.py b/pandas/tests/apply/test_series_apply.py
index 425d2fb42a711..3e0ff19ae4c1a 100644
--- a/pandas/tests/apply/test_series_apply.py
+++ b/pandas/tests/apply/test_series_apply.py
@@ -271,6 +271,19 @@ def test_apply_empty_integer_series_with_datetime_index(by_row):
     tm.assert_series_equal(result, s)
 
 
+def test_apply_dataframe_iloc():
+    uintDF = DataFrame(np.uint64([1, 2, 3, 4, 5]), columns=["Numbers"])
+    indexDF = DataFrame([2, 3, 2, 1, 2], columns=["Indices"])
+
+    def retrieve(targetRow, targetDF):
+        val = targetDF["Numbers"].iloc[targetRow]
+        return val
+
+    result = indexDF["Indices"].apply(retrieve, args=(uintDF,))
+    expected = Series([3, 4, 3, 2, 3], name="Indices", dtype="uint64")
+    tm.assert_series_equal(result, expected)
+
+
 def test_transform(string_series, by_row):
     # transforming functions