diff --git a/pandas/core/generic.py b/pandas/core/generic.py
index 91083f4018c06..b1e4e114c1833 100644
--- a/pandas/core/generic.py
+++ b/pandas/core/generic.py
@@ -15,6 +15,7 @@
     Callable,
     ClassVar,
     Hashable,
+    Iterable,
     Iterator,
     Literal,
     Mapping,
@@ -3604,6 +3605,8 @@ def to_csv(
         decimal: str = ...,
         errors: OpenFileErrors = ...,
         storage_options: StorageOptions = ...,
+        comment: str | None = ...,
+        comment_lines: Iterable[str] | None = ...,
     ) -> str:
         ...
 
@@ -3631,6 +3634,8 @@ def to_csv(
         decimal: str = ...,
         errors: OpenFileErrors = ...,
         storage_options: StorageOptions = ...,
+        comment: str | None = ...,
+        comment_lines: Iterable[str] | None = ...,
     ) -> None:
         ...
 
@@ -3662,6 +3667,8 @@ def to_csv(
         decimal: str = ".",
         errors: OpenFileErrors = "strict",
         storage_options: StorageOptions = None,
+        comment: str | None = None,
+        comment_lines: Iterable[str] | None = None,
     ) -> str | None:
         r"""
         Write object to a comma-separated values (csv) file.
@@ -3767,6 +3774,16 @@ def to_csv(
 
             .. versionadded:: 1.2.0
 
+        comment : str, default None
+            Prefix which should be written to lines preceding the body
+            of an output csv. These lines can be used for comments or
+            metadata which are not part of the csv data itself. Complement
+            of pd.read_csv 'comment' param.
+        comment_lines : Iterable['str'], default None
+            Comment or metadata lines to write to the beginning of the csv
+            file. Each item is a row and will be prefixed with the character in
+            the 'comment' param.
+
         Returns
         -------
         None or str
@@ -3833,6 +3850,8 @@ def to_csv(
             doublequote=doublequote,
             escapechar=escapechar,
             storage_options=storage_options,
+            comment=comment,
+            comment_lines=comment_lines,
         )
 
     # ----------------------------------------------------------------------
diff --git a/pandas/io/formats/csvs.py b/pandas/io/formats/csvs.py
index 672f7c1f71b15..f1c05bbe76327 100644
--- a/pandas/io/formats/csvs.py
+++ b/pandas/io/formats/csvs.py
@@ -10,6 +10,7 @@
     TYPE_CHECKING,
     Any,
     Hashable,
+    Iterable,
     Iterator,
     Sequence,
     cast,
@@ -67,6 +68,8 @@ def __init__(
         doublequote: bool = True,
         escapechar: str | None = None,
         storage_options: StorageOptions = None,
+        comment: str | None = None,
+        comment_lines: Iterable[str] | None = None,
     ) -> None:
         self.fmt = formatter
 
@@ -89,6 +92,8 @@ def __init__(
         self.date_format = date_format
         self.cols = self._initialize_columns(cols)
         self.chunksize = self._initialize_chunksize(chunksize)
+        self.comment = comment
+        self.comment_lines = comment_lines
 
     @property
     def na_rep(self) -> str:
@@ -260,6 +265,8 @@ def save(self) -> None:
             self._save()
 
     def _save(self) -> None:
+        if self.comment:
+            self._save_comment_lines()
         if self._need_to_save_header:
             self._save_header()
         self._save_body()
@@ -318,3 +325,8 @@ def _save_chunk(self, start_i: int, end_i: int) -> None:
             self.cols,
             self.writer,
         )
+
+    def _save_comment_lines(self) -> None:
+        if self.comment_lines:
+            for line in self.comment_lines:
+                self.writer.writerow([f"{self.comment}" + line])
diff --git a/pandas/io/formats/format.py b/pandas/io/formats/format.py
index a425944647b5c..96e40304ace39 100644
--- a/pandas/io/formats/format.py
+++ b/pandas/io/formats/format.py
@@ -1117,6 +1117,8 @@ def to_csv(
         escapechar: str | None = None,
         errors: str = "strict",
         storage_options: StorageOptions = None,
+        comment: str | None = None,
+        comment_lines: Iterable[str] | None = None,
     ) -> str | None:
         """
         Render dataframe as comma-separated file.
@@ -1147,6 +1149,8 @@ def to_csv(
             escapechar=escapechar,
             storage_options=storage_options,
             formatter=self.fmt,
+            comment=comment,
+            comment_lines=comment_lines,
         )
         csv_formatter.save()
 
diff --git a/pandas/tests/io/conftest.py b/pandas/tests/io/conftest.py
index b863e85cae457..b84a18538308f 100644
--- a/pandas/tests/io/conftest.py
+++ b/pandas/tests/io/conftest.py
@@ -36,6 +36,13 @@ def salaries_table(datapath):
     return read_csv(datapath("io", "parser", "data", "salaries.csv"), sep="\t")
 
 
+@pytest.fixture
+def salaries_table_comments(datapath):
+    return read_csv(
+        datapath("io", "parser", "data", "salaries_comments.csv"), sep="\t", comment="#"
+    )
+
+
 @pytest.fixture
 def feather_file(datapath):
     return datapath("io", "data", "feather", "feather-0_3_1.feather")
diff --git a/pandas/tests/io/parser/data/salaries_comments.csv b/pandas/tests/io/parser/data/salaries_comments.csv
new file mode 100644
index 0000000000000..3384ce64c4dd0
--- /dev/null
+++ b/pandas/tests/io/parser/data/salaries_comments.csv
@@ -0,0 +1,50 @@
+#line one
+#line_two
+#three lines_hello_world
+S	X	E	M
+13876	1	1	1
+11608	1	3	0
+18701	1	3	1
+11283	1	2	0
+11767	1	3	0
+20872	2	2	1
+11772	2	2	0
+10535	2	1	0
+12195	2	3	0
+12313	3	2	0
+14975	3	1	1
+21371	3	2	1
+19800	3	3	1
+11417	4	1	0
+20263	4	3	1
+13231	4	3	0
+12884	4	2	0
+13245	5	2	0
+13677	5	3	0
+15965	5	1	1
+12336	6	1	0
+21352	6	3	1
+13839	6	2	0
+22884	6	2	1
+16978	7	1	1
+14803	8	2	0
+17404	8	1	1
+22184	8	3	1
+13548	8	1	0
+14467	10	1	0
+15942	10	2	0
+23174	10	3	1
+23780	10	2	1
+25410	11	2	1
+14861	11	1	0
+16882	12	2	0
+24170	12	3	1
+15990	13	1	0
+26330	13	2	1
+17949	14	2	0
+25685	15	3	1
+27837	16	2	1
+18838	16	2	0
+17483	16	1	0
+19207	17	2	0
+19346	20	1	0
diff --git a/pandas/tests/io/test_common.py b/pandas/tests/io/test_common.py
index 435b9bdade944..2136a0275dd00 100644
--- a/pandas/tests/io/test_common.py
+++ b/pandas/tests/io/test_common.py
@@ -3,6 +3,7 @@
 """
 import codecs
 import errno
+import filecmp
 from functools import partial
 from io import (
     BytesIO,
@@ -620,3 +621,23 @@ def test_pickle_reader(reader):
     # GH 22265
     with BytesIO() as buffer:
         pickle.dump(reader, buffer)
+
+
+def test_comment_writer(salaries_table, salaries_table_comments, datapath):
+    comment = "#"
+    comment_lines = ["line one", "line_two", "three lines_hello_world"]
+    tm.assert_frame_equal(salaries_table, salaries_table_comments)
+    with tm.ensure_clean() as path:
+        # Check commented table can be read and matches non-commented version
+        tm.assert_frame_equal(salaries_table, salaries_table_comments)
+
+        # Write comments on uncommented table then validate
+        salaries_table.to_csv(
+            path, sep="\t", comment=comment, comment_lines=comment_lines, index=False
+        )
+
+        assert filecmp.cmp(
+            path,
+            datapath("io", "parser", "data", "salaries_comments.csv"),
+            shallow=False,
+        ), "Generated csv file with comments does not match expectation"