diff --git a/doc/source/whatsnew/v2.0.1.rst b/doc/source/whatsnew/v2.0.1.rst
index 882b600278c88..caf237fb15163 100644
--- a/doc/source/whatsnew/v2.0.1.rst
+++ b/doc/source/whatsnew/v2.0.1.rst
@@ -14,6 +14,7 @@ including other versions of pandas.
 Fixed regressions
 ~~~~~~~~~~~~~~~~~
 - Fixed regression for subclassed Series when constructing from a dictionary (:issue:`52445`)
+- Fixed regression in :meth:`Series.describe` showing ``RuntimeWarning`` for extension dtype :class:`Series` with one element (:issue:`52515`)
 
 .. ---------------------------------------------------------------------------
 .. _whatsnew_201.bug_fixes:
diff --git a/pandas/core/array_algos/masked_reductions.py b/pandas/core/array_algos/masked_reductions.py
index 7900bcc6a8e6e..60a8d349984b9 100644
--- a/pandas/core/array_algos/masked_reductions.py
+++ b/pandas/core/array_algos/masked_reductions.py
@@ -8,6 +8,7 @@
     TYPE_CHECKING,
     Callable,
 )
+import warnings
 
 import numpy as np
 
@@ -171,9 +172,11 @@ def var(
     if not values.size or mask.all():
         return libmissing.NA
 
-    return _reductions(
-        np.var, values=values, mask=mask, skipna=skipna, axis=axis, ddof=ddof
-    )
+    with warnings.catch_warnings():
+        warnings.simplefilter("ignore", RuntimeWarning)
+        return _reductions(
+            np.var, values=values, mask=mask, skipna=skipna, axis=axis, ddof=ddof
+        )
 
 
 def std(
@@ -187,6 +190,8 @@ def std(
     if not values.size or mask.all():
         return libmissing.NA
 
-    return _reductions(
-        np.std, values=values, mask=mask, skipna=skipna, axis=axis, ddof=ddof
-    )
+    with warnings.catch_warnings():
+        warnings.simplefilter("ignore", RuntimeWarning)
+        return _reductions(
+            np.std, values=values, mask=mask, skipna=skipna, axis=axis, ddof=ddof
+        )
diff --git a/pandas/tests/extension/base/dim2.py b/pandas/tests/extension/base/dim2.py
index 6371411f9992c..6e717afaeeb2d 100644
--- a/pandas/tests/extension/base/dim2.py
+++ b/pandas/tests/extension/base/dim2.py
@@ -12,7 +12,6 @@
 )
 
 import pandas as pd
-import pandas._testing as tm
 from pandas.core.arrays.integer import INT_STR_TO_DTYPE
 from pandas.tests.extension.base.base import BaseExtensionTests
 
@@ -200,12 +199,7 @@ def test_reductions_2d_axis0(self, data, method):
             kwargs["ddof"] = 0
 
         try:
-            if method in ["mean", "var", "std"] and hasattr(data, "_mask"):
-                # Empty slices produced by the mask cause RuntimeWarnings by numpy
-                with tm.assert_produces_warning(RuntimeWarning, check_stacklevel=False):
-                    result = getattr(arr2d, method)(axis=0, **kwargs)
-            else:
-                result = getattr(arr2d, method)(axis=0, **kwargs)
+            result = getattr(arr2d, method)(axis=0, **kwargs)
         except Exception as err:
             try:
                 getattr(data, method)()
diff --git a/pandas/tests/frame/methods/test_describe.py b/pandas/tests/frame/methods/test_describe.py
index ecd784ca5658e..e2b8a0f63c31a 100644
--- a/pandas/tests/frame/methods/test_describe.py
+++ b/pandas/tests/frame/methods/test_describe.py
@@ -388,9 +388,7 @@ def test_ea_with_na(self, any_numeric_ea_dtype):
         # GH#48778
 
         df = DataFrame({"a": [1, pd.NA, pd.NA], "b": pd.NA}, dtype=any_numeric_ea_dtype)
-        # Warning from numpy for taking std of single element
-        with tm.assert_produces_warning(RuntimeWarning, check_stacklevel=False):
-            result = df.describe()
+        result = df.describe()
         expected = DataFrame(
             {"a": [1.0, 1.0, pd.NA] + [1.0] * 5, "b": [0.0] + [pd.NA] * 7},
             index=["count", "mean", "std", "min", "25%", "50%", "75%", "max"],
diff --git a/pandas/tests/series/methods/test_describe.py b/pandas/tests/series/methods/test_describe.py
index ab4b8881d677d..0062d45cc68a0 100644
--- a/pandas/tests/series/methods/test_describe.py
+++ b/pandas/tests/series/methods/test_describe.py
@@ -9,6 +9,7 @@
 )
 
 from pandas import (
+    NA,
     Period,
     Series,
     Timedelta,
@@ -187,3 +188,15 @@ def test_numeric_result_dtype(self, any_numeric_dtype):
             dtype=dtype,
         )
         tm.assert_series_equal(result, expected)
+
+    def test_describe_one_element_ea(self):
+        # GH#52515
+        ser = Series([0.0], dtype="Float64")
+        with tm.assert_produces_warning(None):
+            result = ser.describe()
+        expected = Series(
+            [1, 0, NA, 0, 0, 0, 0, 0],
+            dtype="Float64",
+            index=["count", "mean", "std", "min", "25%", "50%", "75%", "max"],
+        )
+        tm.assert_series_equal(result, expected)