diff --git a/doc/source/whatsnew/v2.1.0.rst b/doc/source/whatsnew/v2.1.0.rst
index bac567b537edc..4486d9217bfae 100644
--- a/doc/source/whatsnew/v2.1.0.rst
+++ b/doc/source/whatsnew/v2.1.0.rst
@@ -154,6 +154,7 @@ Datetimelike
 - Bug in :meth:`Timestamp.round` with values close to the implementation bounds returning incorrect results instead of raising ``OutOfBoundsDatetime`` (:issue:`51494`)
 - :meth:`arrays.DatetimeArray.map` can now take a ``na_action`` argument. :meth:`DatetimeIndex.map` with ``na_action="ignore"`` now works as expected. (:issue:`51644`)
 - Bug in :meth:`arrays.DatetimeArray.map` and :meth:`DatetimeIndex.map`, where the supplied callable operated array-wise instead of element-wise (:issue:`51977`)
+- Bug in :class:`Timestamp` raising an error when passing fold when constructing from positional arguments.
 -
 
 Timedelta
diff --git a/pandas/_libs/tslibs/timestamps.pyx b/pandas/_libs/tslibs/timestamps.pyx
index 10a331f302cc4..6307323d42f2f 100644
--- a/pandas/_libs/tslibs/timestamps.pyx
+++ b/pandas/_libs/tslibs/timestamps.pyx
@@ -1269,7 +1269,23 @@ cdef class _Timestamp(ABCTimestamp):
 # Python front end to C extension type _Timestamp
 # This serves as the box for datetime64
 
+def _fix_positional_arguments(cls):
+    original_new = cls.__new__
+
+    def updated_new(cls, *args, **kwargs):
+        # GH#52117 If we passed positional args, then _ts_input
+        # is now set to year and the other positional args
+        # are shifted to the left. Let's shift back
+        if len(args) > 2 and all(isinstance(arg, int) for arg in args[:3]):
+            return original_new(cls, _no_input, *args, **kwargs)
+        else:
+            return original_new(cls, *args, **kwargs)
+
+    cls.__new__ = updated_new
+    return cls
+
 
+@_fix_positional_arguments
 class Timestamp(_Timestamp):
     """
     Pandas replacement for python datetime.datetime object.
diff --git a/pandas/tests/scalar/timestamp/test_constructors.py b/pandas/tests/scalar/timestamp/test_constructors.py
index 02244c1686cab..8c88ceac7d8c9 100644
--- a/pandas/tests/scalar/timestamp/test_constructors.py
+++ b/pandas/tests/scalar/timestamp/test_constructors.py
@@ -340,12 +340,7 @@ def test_constructor_positional_with_tzinfo(self):
 
     @pytest.mark.parametrize("kwd", ["nanosecond", "microsecond", "second", "minute"])
     def test_constructor_positional_keyword_mixed_with_tzinfo(self, kwd, request):
-        # TODO: if we passed microsecond with a keyword we would mess up
-        #  xref GH#45307
-        if kwd != "nanosecond":
-            # nanosecond is keyword-only as of 2.0, others are not
-            mark = pytest.mark.xfail(reason="GH#45307")
-            request.node.add_marker(mark)
+        # GH#52221 makes a mix of positional and keyword arguments behave consistently
 
         kwargs = {kwd: 4}
         ts = Timestamp(2020, 12, 31, tzinfo=timezone.utc, **kwargs)
@@ -899,3 +894,21 @@ def test_timestamp_constructor_adjust_value_for_fold(tz, ts_input, fold, value_o
     result = ts._value
     expected = value_out
     assert result == expected
+
+
+@pytest.mark.parametrize("tz", ["dateutil/Europe/London"])
+def test_timestamp_constructor_positional_with_fold(tz):
+    # Check that we build an object successfully
+    # if we pass positional arguments and fold
+    ts = Timestamp(2019, 10, 27, 1, 30, tz=tz, fold=0)
+    result = ts._value
+    expected = 1572136200000000
+    assert result == expected
+
+
+def test_timestamp_constructor_arg_shift():
+    # Check that passing a positional argument as keyword
+    # does not change the value
+    result = Timestamp(2019, 10, 27, minute=30)
+    expected = Timestamp(2019, 10, 27, 0, 30)
+    assert result == expected