diff --git a/pandas/core/frame.py b/pandas/core/frame.py
index 33d503f3dd4cb..59ebf9f55e558 100644
--- a/pandas/core/frame.py
+++ b/pandas/core/frame.py
@@ -3869,23 +3869,27 @@ def _get_value(self, index, col, takeable: bool = False) -> Scalar:
 
     def isetitem(self, loc, value) -> None:
         """
-        Set the given value in the column with position 'loc'.
+        Set the given value in the column with position `loc`.
 
-        This is a positional analogue to __setitem__.
+        This is a positional analogue to ``__setitem__``.
 
         Parameters
         ----------
         loc : int or sequence of ints
+            Index position for the column.
         value : scalar or arraylike
+            Value(s) for the column.
 
         Notes
         -----
-        Unlike `frame.iloc[:, i] = value`, `frame.isetitem(loc, value)` will
-        _never_ try to set the values in place, but will always insert a new
-        array.
-
-        In cases where `frame.columns` is unique, this is equivalent to
-        `frame[frame.columns[i]] = value`.
+        ``frame.isetitem(loc, value)`` is an in-place method as it will
+        modify the DataFrame in place (not returning a new object). In contrast to
+        ``frame.iloc[:, i] = value`` which will try to update the existing values in
+        place, ``frame.isetitem(loc, value)`` will not update the values of the column
+        itself in place, it will instead insert a new array.
+
+        In cases where ``frame.columns`` is unique, this is equivalent to
+        ``frame[frame.columns[i]] = value``.
         """
         if isinstance(value, DataFrame):
             if is_scalar(loc):