diff --git a/doc/source/whatsnew/v2.0.0.rst b/doc/source/whatsnew/v2.0.0.rst
index c3481a5452091..2258c76a6cff5 100644
--- a/doc/source/whatsnew/v2.0.0.rst
+++ b/doc/source/whatsnew/v2.0.0.rst
@@ -780,7 +780,7 @@ Deprecations
 - :meth:`Index.is_object` has been deprecated. Use :func:`pandas.api.types.is_object_dtype` instead (:issue:`50042`)
 - :meth:`Index.is_interval` has been deprecated. Use :func:`pandas.api.types.is_intterval_dtype` instead (:issue:`50042`)
 - Deprecated ``all`` and ``any`` reductions with ``datetime64`` and :class:`DatetimeTZDtype` dtypes, use e.g. ``(obj != pd.Timestamp(0), tz=obj.tz).all()`` instead (:issue:`34479`)
--
+- Deprecated calling ``float`` or ``int`` on a single element :class:`Series` to return a ``float`` or ``int`` respectively. Extract the element before calling ``float`` or ``int`` instead (:issue:`51101`)
 
 .. ---------------------------------------------------------------------------
 .. _whatsnew_200.prior_deprecations:
diff --git a/pandas/core/series.py b/pandas/core/series.py
index abe31d0dbd52a..9a5412145366f 100644
--- a/pandas/core/series.py
+++ b/pandas/core/series.py
@@ -19,6 +19,7 @@
     cast,
     overload,
 )
+import warnings
 import weakref
 
 import numpy as np
@@ -81,6 +82,7 @@
     Substitution,
     doc,
 )
+from pandas.util._exceptions import find_stack_level
 from pandas.util._validators import (
     validate_ascending,
     validate_bool_kwarg,
@@ -216,6 +218,13 @@ def _coerce_method(converter):
 
     def wrapper(self):
         if len(self) == 1:
+            warnings.warn(
+                f"Calling {converter.__name__} on a single element Series is "
+                "deprecated and will raise a TypeError in the future. "
+                f"Use {converter.__name__}(ser.iloc[0]) instead",
+                FutureWarning,
+                stacklevel=find_stack_level(),
+            )
             return converter(self.iloc[0])
         raise TypeError(f"cannot convert the series to {converter}")
 
diff --git a/pandas/tests/apply/test_invalid_arg.py b/pandas/tests/apply/test_invalid_arg.py
index 3f2e8e9ea07a6..101e7be70e691 100644
--- a/pandas/tests/apply/test_invalid_arg.py
+++ b/pandas/tests/apply/test_invalid_arg.py
@@ -277,7 +277,7 @@ def test_agg_none_to_type():
     df = DataFrame({"a": [None]})
     msg = re.escape("int() argument must be a string")
     with pytest.raises(TypeError, match=msg):
-        df.agg({"a": int})
+        df.agg({"a": lambda x: int(x.iloc[0])})
 
 
 def test_transform_none_to_type():
@@ -285,7 +285,7 @@ def test_transform_none_to_type():
     df = DataFrame({"a": [None]})
     msg = "argument must be a"
     with pytest.raises(TypeError, match=msg):
-        df.transform({"a": int})
+        df.transform({"a": lambda x: int(x.iloc[0])})
 
 
 @pytest.mark.parametrize(
diff --git a/pandas/tests/series/test_api.py b/pandas/tests/series/test_api.py
index 4852788ef2c06..5c3dfd246e9aa 100644
--- a/pandas/tests/series/test_api.py
+++ b/pandas/tests/series/test_api.py
@@ -287,3 +287,10 @@ def test_numeric_only(self, kernel, has_numeric_only, dtype):
             else:
                 # reducer
                 assert result == expected
+
+
+@pytest.mark.parametrize("converter", [int, float, complex])
+def test_float_int_deprecated(converter):
+    # GH 51101
+    with tm.assert_produces_warning(FutureWarning):
+        assert converter(Series([1])) == converter(1)
diff --git a/pandas/tests/series/test_constructors.py b/pandas/tests/series/test_constructors.py
index bd6db2befdb0b..49c5b78a48a9f 100644
--- a/pandas/tests/series/test_constructors.py
+++ b/pandas/tests/series/test_constructors.py
@@ -145,10 +145,6 @@ def test_scalar_conversion(self):
         scalar = Series(0.5)
         assert not isinstance(scalar, float)
 
-        # Coercion
-        assert float(Series([1.0])) == 1.0
-        assert int(Series([1.0])) == 1
-
     def test_scalar_extension_dtype(self, ea_scalar_and_dtype):
         # GH 28401