diff --git a/pandas/tests/arithmetic/test_numeric.py b/pandas/tests/arithmetic/test_numeric.py
index 93225d937697f..fea216c35129b 100644
--- a/pandas/tests/arithmetic/test_numeric.py
+++ b/pandas/tests/arithmetic/test_numeric.py
@@ -1463,3 +1463,17 @@ def test_empty_str_comparison(power, string_size):
     result = right == left
     expected = pd.DataFrame(np.zeros(right.shape, dtype=bool))
     tm.assert_frame_equal(result, expected)
+
+
+def test_series_add_sub_with_UInt64():
+    # GH 22023
+    series1 = Series([1, 2, 3])
+    series2 = Series([2, 1, 3], dtype="UInt64")
+
+    result = series1 + series2
+    expected = Series([3, 3, 6], dtype="Float64")
+    tm.assert_series_equal(result, expected)
+
+    result = series1 - series2
+    expected = Series([-1, 1, 0], dtype="Float64")
+    tm.assert_series_equal(result, expected)