diff --git a/doc/source/whatsnew/v2.0.0.rst b/doc/source/whatsnew/v2.0.0.rst
index 9a99dbad30708..39a93304bfe5a 100644
--- a/doc/source/whatsnew/v2.0.0.rst
+++ b/doc/source/whatsnew/v2.0.0.rst
@@ -556,9 +556,10 @@ Other API changes
 Deprecations
 ~~~~~~~~~~~~
 - Deprecated argument ``infer_datetime_format`` in :func:`to_datetime` and :func:`read_csv`, as a strict version of it is now the default (:issue:`48621`)
+- Deprecated :func:`pandas.io.sql.execute`(:issue:`50185`)
+-
 
 .. ---------------------------------------------------------------------------
-
 .. _whatsnew_200.prior_deprecations:
 
 Removal of prior version deprecations/changes
diff --git a/pandas/io/sql.py b/pandas/io/sql.py
index 2b845786b0366..eea97fc0d9760 100644
--- a/pandas/io/sql.py
+++ b/pandas/io/sql.py
@@ -201,6 +201,12 @@ def execute(sql, con, params=None):
     -------
     Results Iterable
     """
+    warnings.warn(
+        "`pandas.io.sql.execute` is deprecated and "
+        "will be removed in the future version.",
+        FutureWarning,
+        stacklevel=find_stack_level(),
+    )  # GH50185
     sqlalchemy = import_optional_dependency("sqlalchemy", errors="ignore")
 
     if sqlalchemy is not None and isinstance(con, (str, sqlalchemy.engine.Engine)):
diff --git a/pandas/tests/io/test_sql.py b/pandas/tests/io/test_sql.py
index 31ca060e36ad1..f83b6b0373a87 100644
--- a/pandas/tests/io/test_sql.py
+++ b/pandas/tests/io/test_sql.py
@@ -668,6 +668,16 @@ def test_execute_typeerror(sqlite_iris_engine):
         sql.execute("select * from iris", sqlite_iris_engine)
 
 
+def test_execute_deprecated(sqlite_buildin_iris):
+    # GH50185
+    with tm.assert_produces_warning(
+        FutureWarning,
+        match="`pandas.io.sql.execute` is deprecated and "
+        "will be removed in the future version.",
+    ):
+        sql.execute("select * from iris", sqlite_buildin_iris)
+
+
 class MixInBase:
     def teardown_method(self):
         # if setup fails, there may not be a connection to close.