diff --git a/pandas/core/apply.py b/pandas/core/apply.py
index 6d9f5510eb8c5..722de91ba5246 100644
--- a/pandas/core/apply.py
+++ b/pandas/core/apply.py
@@ -663,12 +663,6 @@ def agg(self):
         result = None
         try:
             result = super().agg()
-        except TypeError as err:
-            exc = TypeError(
-                "DataFrame constructor called with "
-                f"incompatible data and dtype: {err}"
-            )
-            raise exc from err
         finally:
             self.obj = obj
             self.axis = axis
diff --git a/pandas/tests/apply/test_frame_apply.py b/pandas/tests/apply/test_frame_apply.py
index 28c776d0a6d35..7bf1621d0acea 100644
--- a/pandas/tests/apply/test_frame_apply.py
+++ b/pandas/tests/apply/test_frame_apply.py
@@ -1181,8 +1181,7 @@ def test_agg_multiple_mixed_raises():
     )
 
     # sorted index
-    # TODO: GH#49399 will fix error message
-    msg = "DataFrame constructor called with"
+    msg = "does not support reduction"
     with pytest.raises(TypeError, match=msg):
         mdf.agg(["min", "sum"])
 
@@ -1283,7 +1282,7 @@ def test_nuiscance_columns():
     )
     tm.assert_frame_equal(result, expected)
 
-    msg = "DataFrame constructor called with incompatible data and dtype"
+    msg = "does not support reduction"
     with pytest.raises(TypeError, match=msg):
         df.agg("sum")
 
@@ -1291,8 +1290,7 @@ def test_nuiscance_columns():
     expected = Series([6, 6.0, "foobarbaz"], index=["A", "B", "C"])
     tm.assert_series_equal(result, expected)
 
-    # TODO: GH#49399 will fix error message
-    msg = "DataFrame constructor called with"
+    msg = "does not support reduction"
     with pytest.raises(TypeError, match=msg):
         df.agg(["sum"])