diff --git a/pandas/_testing/asserters.py b/pandas/_testing/asserters.py
index a5641465b0be0..0c99ae4b8e03d 100644
--- a/pandas/_testing/asserters.py
+++ b/pandas/_testing/asserters.py
@@ -877,7 +877,7 @@ def assert_series_equal(
         )
 
     if check_like:
-        left, right = left.reindex_like(right), right
+        left = left.reindex_like(right)
 
     if check_freq and isinstance(left.index, (DatetimeIndex, TimedeltaIndex)):
         lidx = left.index
@@ -1159,7 +1159,7 @@ def assert_frame_equal(
     )
 
     if check_like:
-        left, right = left.reindex_like(right), right
+        left = left.reindex_like(right)
 
     # compare by blocks
     if by_blocks:
diff --git a/pandas/core/indexes/datetimelike.py b/pandas/core/indexes/datetimelike.py
index b72a6aa83c369..a6c396555e9a7 100644
--- a/pandas/core/indexes/datetimelike.py
+++ b/pandas/core/indexes/datetimelike.py
@@ -446,7 +446,6 @@ def _wrap_range_setop(self, other, res_i8):
             new_freq = self.freq
         elif isinstance(res_i8, RangeIndex):
             new_freq = to_offset(Timedelta(res_i8.step))
-            res_i8 = res_i8
 
         # TODO(GH#41493): we cannot just do
         #  type(self._data)(res_i8.values, dtype=self.dtype, freq=new_freq)
diff --git a/pandas/tests/indexes/multi/test_reindex.py b/pandas/tests/indexes/multi/test_reindex.py
index 7ef739056ada8..8cf729454c15a 100644
--- a/pandas/tests/indexes/multi/test_reindex.py
+++ b/pandas/tests/indexes/multi/test_reindex.py
@@ -90,7 +90,6 @@ def test_reindex_lvl_preserves_type_if_target_is_empty_list_or_array():
 
 
 def test_reindex_base(idx):
-    idx = idx
     expected = np.arange(idx.size, dtype=np.intp)
 
     actual = idx.get_indexer(idx)
diff --git a/pandas/tests/indexes/multi/test_take.py b/pandas/tests/indexes/multi/test_take.py
index f8e7632c91ab2..543cba25c373b 100644
--- a/pandas/tests/indexes/multi/test_take.py
+++ b/pandas/tests/indexes/multi/test_take.py
@@ -18,7 +18,6 @@ def test_take(idx):
 
 
 def test_take_invalid_kwargs(idx):
-    idx = idx
     indices = [1, 2]
 
     msg = r"take\(\) got an unexpected keyword argument 'foo'"
diff --git a/pandas/tests/reshape/merge/test_merge_asof.py b/pandas/tests/reshape/merge/test_merge_asof.py
index ebf67b0518c65..4d9c200fcaed6 100644
--- a/pandas/tests/reshape/merge/test_merge_asof.py
+++ b/pandas/tests/reshape/merge/test_merge_asof.py
@@ -210,7 +210,6 @@ def test_basic_left_index(self, trades, asof, quotes):
     def test_basic_right_index(self, trades, asof, quotes):
 
         expected = asof
-        trades = trades
         quotes = quotes.set_index("time")
 
         result = merge_asof(
diff --git a/pyproject.toml b/pyproject.toml
index 7b4c9425d557c..d3065ae7b129a 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -147,7 +147,6 @@ disable = [
   "raise-missing-from",
   "redefined-builtin",
   "redefined-outer-name",
-  "self-assigning-variable",
   "self-cls-assignment",
   "signature-differs",
   "super-init-not-called",