diff --git a/pandas/tests/frame/methods/test_replace.py b/pandas/tests/frame/methods/test_replace.py
index 626bc658b199c..1a1a456152592 100644
--- a/pandas/tests/frame/methods/test_replace.py
+++ b/pandas/tests/frame/methods/test_replace.py
@@ -1503,6 +1503,13 @@ def test_replace_value_none_dtype_numeric(self, val):
         result = df.replace({val: None})
         tm.assert_frame_equal(result, expected)
 
+    def test_replace_in_col_containing_na(self):
+        # GH#47480
+        df = DataFrame({"A": [pd.NA, 1, 2]}, dtype="Int64")
+        df["A"].replace(to_replace=1, value=100, inplace=True)
+        expected = DataFrame({"A": [pd.NA, 100, 2]}, dtype="Int64")
+        tm.assert_frame_equal(df, expected)
+
 
 class TestDataFrameReplaceRegex:
     @pytest.mark.parametrize(