diff --git a/doc/source/whatsnew/v2.1.0.rst b/doc/source/whatsnew/v2.1.0.rst
index 22a2931519ffd..4180cdb245a82 100644
--- a/doc/source/whatsnew/v2.1.0.rst
+++ b/doc/source/whatsnew/v2.1.0.rst
@@ -316,6 +316,7 @@ Conversion
 ^^^^^^^^^^
 - Bug in :func:`DataFrame.style.to_latex` and :func:`DataFrame.style.to_html` if the DataFrame contains integers with more digits than can be represented by floating point double precision (:issue:`52272`)
 - Bug in :meth:`ArrowDtype.numpy_dtype` returning nanosecond units for non-nanosecond ``pyarrow.timestamp`` and ``pyarrow.duration`` types (:issue:`51800`)
+- Bug in :meth:`DataFrame.__repr__` incorrectly raising a ``TypeError`` when the dtype of a column is ``np.record`` (:issue:`48526`)
 - Bug in :meth:`DataFrame.info` raising  ``ValueError`` when ``use_numba`` is set (:issue:`51922`)
 -
 
diff --git a/pandas/core/dtypes/missing.py b/pandas/core/dtypes/missing.py
index 2fb8d3563b792..1b3b8aad6de51 100644
--- a/pandas/core/dtypes/missing.py
+++ b/pandas/core/dtypes/missing.py
@@ -283,6 +283,9 @@ def _isna_array(values: ArrayLike, inf_as_na: bool = False):
             # "Union[ndarray[Any, Any], ExtensionArraySupportsAnyAll]", variable has
             # type "ndarray[Any, dtype[bool_]]")
             result = values.isna()  # type: ignore[assignment]
+    elif isinstance(values, np.recarray):
+        # GH 48526
+        result = _isna_recarray_dtype(values, inf_as_na=inf_as_na)
     elif is_string_or_object_np_dtype(values.dtype):
         result = _isna_string_dtype(values, inf_as_na=inf_as_na)
     elif dtype.kind in "mM":
@@ -314,6 +317,34 @@ def _isna_string_dtype(values: np.ndarray, inf_as_na: bool) -> npt.NDArray[np.bo
     return result
 
 
+def _has_record_inf_value(record_as_array: np.ndarray) -> np.bool_:
+    is_inf_in_record = np.zeros(len(record_as_array), dtype=bool)
+    for i, value in enumerate(record_as_array):
+        is_element_inf = False
+        try:
+            is_element_inf = np.isinf(value)
+        except TypeError:
+            is_element_inf = False
+        is_inf_in_record[i] = is_element_inf
+
+    return np.any(is_inf_in_record)
+
+
+def _isna_recarray_dtype(values: np.recarray, inf_as_na: bool) -> npt.NDArray[np.bool_]:
+    result = np.zeros(values.shape, dtype=bool)
+    for i, record in enumerate(values):
+        record_as_array = np.array(record.tolist())
+        does_record_contain_nan = isna_all(record_as_array)
+        does_record_contain_inf = False
+        if inf_as_na:
+            does_record_contain_inf = bool(_has_record_inf_value(record_as_array))
+        result[i] = np.any(
+            np.logical_or(does_record_contain_nan, does_record_contain_inf)
+        )
+
+    return result
+
+
 @overload
 def notna(obj: Scalar) -> bool:
     ...
diff --git a/pandas/tests/frame/test_repr_info.py b/pandas/tests/frame/test_repr_info.py
index 66d8084abea68..b42af8cdfcd8c 100644
--- a/pandas/tests/frame/test_repr_info.py
+++ b/pandas/tests/frame/test_repr_info.py
@@ -361,6 +361,71 @@ def test_datetime64tz_slice_non_truncate(self):
         result = repr(df)
         assert result == expected
 
+    def test_to_records_no_typeerror_in_repr(self):
+        # GH 48526
+        df = DataFrame([["a", "b"], ["c", "d"], ["e", "f"]], columns=["left", "right"])
+        df["record"] = df[["left", "right"]].to_records()
+        expected = """  left right     record
+0    a     b  [0, a, b]
+1    c     d  [1, c, d]
+2    e     f  [2, e, f]"""
+        result = repr(df)
+        assert result == expected
+
+    def test_to_records_with_na_record_value(self):
+        # GH 48526
+        df = DataFrame(
+            [["a", np.nan], ["c", "d"], ["e", "f"]], columns=["left", "right"]
+        )
+        df["record"] = df[["left", "right"]].to_records()
+        expected = """  left right       record
+0    a   NaN  [0, a, nan]
+1    c     d    [1, c, d]
+2    e     f    [2, e, f]"""
+        result = repr(df)
+        assert result == expected
+
+    def test_to_records_with_na_record(self):
+        # GH 48526
+        df = DataFrame(
+            [["a", "b"], [np.nan, np.nan], ["e", "f"]], columns=[np.nan, "right"]
+        )
+        df["record"] = df[[np.nan, "right"]].to_records()
+        expected = """   NaN right         record
+0    a     b      [0, a, b]
+1  NaN   NaN  [1, nan, nan]
+2    e     f      [2, e, f]"""
+        result = repr(df)
+        assert result == expected
+
+    def test_to_records_with_inf_as_na_record(self):
+        # GH 48526
+        with option_context("use_inf_as_na", True):
+            df = DataFrame(
+                [[np.inf, "b"], [np.nan, np.nan], ["e", "f"]], columns=[np.nan, np.inf]
+            )
+            df["record"] = df[[np.nan, np.inf]].to_records()
+            expected = """   NaN  inf         record
+0  NaN    b    [0, inf, b]
+1  NaN  NaN  [1, nan, nan]
+2    e    f      [2, e, f]"""
+            result = repr(df)
+        assert result == expected
+
+    def test_to_records_with_inf_record(self):
+        # GH 48526
+        with option_context("use_inf_as_na", False):
+            df = DataFrame(
+                [[np.inf, "b"], [np.nan, np.nan], ["e", "f"]], columns=[np.nan, np.inf]
+            )
+            df["record"] = df[[np.nan, np.inf]].to_records()
+            expected = """   NaN  inf         record
+0  inf    b    [0, inf, b]
+1  NaN  NaN  [1, nan, nan]
+2    e    f      [2, e, f]"""
+            result = repr(df)
+        assert result == expected
+
     def test_masked_ea_with_formatter(self):
         # GH#39336
         df = DataFrame(