diff --git a/doc/source/whatsnew/v1.4.4.rst b/doc/source/whatsnew/v1.4.4.rst
index 6ee140f59e096..6bd7378e05404 100644
--- a/doc/source/whatsnew/v1.4.4.rst
+++ b/doc/source/whatsnew/v1.4.4.rst
@@ -15,6 +15,7 @@ including other versions of pandas.
 Fixed regressions
 ~~~~~~~~~~~~~~~~~
 - Fixed regression in :func:`concat` materializing :class:`Index` during sorting even if :class:`Index` was already sorted (:issue:`47501`)
+- Fixed regression in setting ``None`` or non-string value into a ``string``-dtype Series using a mask (:issue:`47628`)
 -
 
 .. ---------------------------------------------------------------------------
diff --git a/pandas/core/arrays/string_.py b/pandas/core/arrays/string_.py
index c9abef226770c..c68ffec600c8a 100644
--- a/pandas/core/arrays/string_.py
+++ b/pandas/core/arrays/string_.py
@@ -14,6 +14,7 @@
 from pandas._typing import (
     Dtype,
     Scalar,
+    npt,
     type_t,
 )
 from pandas.compat import pa_version_under1p01
@@ -410,6 +411,12 @@ def __setitem__(self, key, value):
 
         super().__setitem__(key, value)
 
+    def _putmask(self, mask: npt.NDArray[np.bool_], value) -> None:
+        # the super() method NDArrayBackedExtensionArray._putmask uses
+        # np.putmask which doesn't properly handle None/pd.NA, so using the
+        # base class implementation that uses __setitem__
+        ExtensionArray._putmask(self, mask, value)
+
     def astype(self, dtype, copy: bool = True):
         dtype = pandas_dtype(dtype)
 
diff --git a/pandas/tests/arrays/string_/test_string.py b/pandas/tests/arrays/string_/test_string.py
index a5eb6189db6f1..4376a0de37a8c 100644
--- a/pandas/tests/arrays/string_/test_string.py
+++ b/pandas/tests/arrays/string_/test_string.py
@@ -588,3 +588,23 @@ def test_isin(dtype, fixed_now_ts):
         result = s.isin(["a", fixed_now_ts])
     expected = pd.Series([True, False, False])
     tm.assert_series_equal(result, expected)
+
+
+def test_setitem_scalar_with_mask_validation(dtype):
+    # https://github.com/pandas-dev/pandas/issues/47628
+    # setting None with a boolean mask (through _putmaks) should still result
+    # in pd.NA values in the underlying array
+    ser = pd.Series(["a", "b", "c"], dtype=dtype)
+    mask = np.array([False, True, False])
+
+    ser[mask] = None
+    assert ser.array[1] is pd.NA
+
+    # for other non-string we should also raise an error
+    ser = pd.Series(["a", "b", "c"], dtype=dtype)
+    if type(ser.array) is pd.arrays.StringArray:
+        msg = "Cannot set non-string value"
+    else:
+        msg = "Scalar must be NA or str"
+    with pytest.raises(ValueError, match=msg):
+        ser[mask] = 1