diff --git a/pandas/core/indexing.py b/pandas/core/indexing.py
index 5a97e1d5a04ea..09fa08339bd43 100644
--- a/pandas/core/indexing.py
+++ b/pandas/core/indexing.py
@@ -1977,7 +1977,11 @@ def _setitem_single_column(self, loc: int, value, plane_indexer):
         # We will not operate in-place, but will attempt to in the future.
         #  To determine whether we need to issue a FutureWarning, see if the
         #  setting in-place would work, i.e. behavior will change.
-        warn = can_hold_element(orig_values, value)
+        if isinstance(value, ABCSeries):
+            warn = can_hold_element(orig_values, value._values)
+        else:
+            warn = can_hold_element(orig_values, value)
+
         # Don't issue the warning yet, as we can still trim a few cases where
         #  behavior will not change.
 
diff --git a/pandas/tests/frame/indexing/test_setitem.py b/pandas/tests/frame/indexing/test_setitem.py
index cf6d351aa78a0..a59d7d4f3bd45 100644
--- a/pandas/tests/frame/indexing/test_setitem.py
+++ b/pandas/tests/frame/indexing/test_setitem.py
@@ -683,6 +683,13 @@ def test_boolean_mask_nullable_int64(self):
         )
         tm.assert_frame_equal(result, expected)
 
+    def test_setitem_ea_dtype_rhs_series(self):
+        # GH#47425
+        df = DataFrame({"a": [1, 2]})
+        df["a"] = Series([1, 2], dtype="Int64")
+        expected = DataFrame({"a": [1, 2]}, dtype="Int64")
+        tm.assert_frame_equal(df, expected)
+
     # TODO(ArrayManager) set column with 2d column array, see #44788
     @td.skip_array_manager_not_yet_implemented
     def test_setitem_npmatrix_2d(self):