diff --git a/pandas/core/frame.py b/pandas/core/frame.py
index 39a940169e1f3..8711d53353185 100644
--- a/pandas/core/frame.py
+++ b/pandas/core/frame.py
@@ -8000,7 +8000,7 @@ def update(
             if mask.all():
                 continue
 
-            self[col] = expressions.where(mask, this, that)
+            self.loc[:, col] = expressions.where(mask, this, that)
 
     # ----------------------------------------------------------------------
     # Data reshaping