diff --git a/doc/source/whatsnew/v1.4.4.rst b/doc/source/whatsnew/v1.4.4.rst
index b462f0c6a8ffe..cb2e24437433c 100644
--- a/doc/source/whatsnew/v1.4.4.rst
+++ b/doc/source/whatsnew/v1.4.4.rst
@@ -14,7 +14,7 @@ including other versions of pandas.
 
 Fixed regressions
 ~~~~~~~~~~~~~~~~~
--
+- Fixed regression in taking NULL :class:`objects` from a :class:`DataFrame` causing a segmentation violation. These NULL values are created by :meth:`numpy.empty_like` (:issue:`46848`)
 -
 
 .. ---------------------------------------------------------------------------
diff --git a/pandas/_libs/algos_take_helper.pxi.in b/pandas/_libs/algos_take_helper.pxi.in
index 2a3858674af9e..4f96d5c0adc6c 100644
--- a/pandas/_libs/algos_take_helper.pxi.in
+++ b/pandas/_libs/algos_take_helper.pxi.in
@@ -147,8 +147,15 @@ def take_2d_axis0_{{name}}_{{dest}}(ndarray[{{c_type_in}}, ndim=2] values,
                 {{if c_type_in == "uint8_t" and c_type_out == "object"}}
                 out[i, j] = True if values[idx, j] > 0 else False
                 {{else}}
+                {{if c_type_in == "object"}} # GH46848
+                if values[idx][j] is None:
+                    out[i, j] = None
+                else:
+                    out[i, j] = values[idx, j]
+                {{else}}
                 out[i, j] = values[idx, j]
                 {{endif}}
+                {{endif}}
 
 
 @cython.wraparound(False)
@@ -183,8 +190,15 @@ def take_2d_axis1_{{name}}_{{dest}}(ndarray[{{c_type_in}}, ndim=2] values,
                 {{if c_type_in == "uint8_t" and c_type_out == "object"}}
                 out[i, j] = True if values[i, idx] > 0 else False
                 {{else}}
+                {{if c_type_in == "object"}} # GH46848
+                if values[i][idx] is None:
+                    out[i, j] = None
+                else:
+                    out[i, j] = values[i, idx]
+                {{else}}
                 out[i, j] = values[i, idx]
                 {{endif}}
+                {{endif}}
 
 
 @cython.wraparound(False)
diff --git a/pandas/tests/test_take.py b/pandas/tests/test_take.py
index f0737f7dc4cce..036710dce74fd 100644
--- a/pandas/tests/test_take.py
+++ b/pandas/tests/test_take.py
@@ -6,8 +6,10 @@
 
 from pandas._libs import iNaT
 
+import pandas as pd
 import pandas._testing as tm
 import pandas.core.algorithms as algos
+from pandas.core.array_algos.take import _take_nd_ndarray
 
 
 @pytest.fixture(params=[True, False])
@@ -332,3 +334,25 @@ def test_take_coerces_list(self):
         result = algos.take(arr, [0, 0])
         expected = np.array([1, 1])
         tm.assert_numpy_array_equal(result, expected)
+
+
+class TestTakeNumpyNull:
+    # GH 46848
+
+    def test_take_2d_axis0_object_object(self):
+        arr = np.array([[None]], dtype=object)
+        indexer = np.array([0])
+        axis = 1
+        fill_value = None
+        allow_fill = False
+
+        result = _take_nd_ndarray(arr, indexer, axis, fill_value, allow_fill)
+        assert result == [[None]]
+        arr2 = np.empty_like(arr)
+        result2 = _take_nd_ndarray(arr2, indexer, axis, fill_value, allow_fill)
+        assert result2 == [[None]]
+
+    def test_take_2d_axis1_object_object(self):
+        df = pd.DataFrame(np.empty((1, 1), dtype=object))
+        df[0] = np.empty_like(df[0])
+        df[[0]]