diff --git a/doc/source/whatsnew/v1.5.0.rst b/doc/source/whatsnew/v1.5.0.rst
index 6bf6fd65f5633..0f361ca9a74a9 100644
--- a/doc/source/whatsnew/v1.5.0.rst
+++ b/doc/source/whatsnew/v1.5.0.rst
@@ -862,6 +862,7 @@ Groupby/resample/rolling
 - Bug in :meth:`Rolling.skew` and :meth:`Rolling.kurt` would give NaN with window of same values (:issue:`30993`)
 - Bug in :meth:`.Rolling.var` would segfault calculating weighted variance when window size was larger than data size (:issue:`46760`)
 - Bug in :meth:`Grouper.__repr__` where ``dropna`` was not included. Now it is (:issue:`46754`)
+- Bug in :meth:`Rolling.aggregate` raise ValueError when ``func`` was a list of functions and ``axis=1`` (:issue:`46132`)
 - Bug in :meth:`DataFrame.rolling` gives ValueError when center=True, axis=1 and win_type is specified (:issue:`46135`)
 - Bug in :meth:`.DataFrameGroupBy.describe` and :meth:`.SeriesGroupBy.describe` produces inconsistent results for empty datasets (:issue:`41575`)
 - Bug in :meth:`DataFrame.resample` reduction methods when used with ``on`` would attempt to aggregate the provided column (:issue:`47079`)
diff --git a/pandas/core/window/rolling.py b/pandas/core/window/rolling.py
index 9e8f95cf340c4..42343ad0c42c0 100644
--- a/pandas/core/window/rolling.py
+++ b/pandas/core/window/rolling.py
@@ -656,9 +656,28 @@ def _numba_apply(
             return self._resolve_output(out, obj)
 
     def aggregate(self, func, *args, **kwargs):
-        result = ResamplerWindowApply(self, func, args=args, kwargs=kwargs).agg()
+        # GH46132
+        # modifying axis and transposing dataframe should not be needed
+        # once ReamplerWindow supports axis = 1
+
+        obj = self.obj
+        axis = self.axis
+
+        self.obj = self.obj.T if self.axis == 1 else self.obj
+        self.axis = 0
+
+        try:
+            result = ResamplerWindowApply(self, func, args=args, kwargs=kwargs).agg()
+        finally:
+            self.obj = obj
+            self.axis = axis
+
+        if axis == 1:
+            result = result.T if result is not None else result
+
         if result is None:
             return self.apply(func, raw=False, args=args, kwargs=kwargs)
+
         return result
 
     agg = aggregate
diff --git a/pandas/tests/window/test_rolling.py b/pandas/tests/window/test_rolling.py
index 4c26cfb95fd85..35bd4853df515 100644
--- a/pandas/tests/window/test_rolling.py
+++ b/pandas/tests/window/test_rolling.py
@@ -1851,6 +1851,22 @@ def test_rolling_var_same_value_count_logic(values, window, min_periods, expecte
     tm.assert_series_equal(expected == 0, result_std == 0)
 
 
+def test_rolling_agg_on_columns():
+    # GH 46132
+
+    df = DataFrame({"a": [1, 3], "b": [2, 4]})
+    res = df.rolling(window=2, axis=1, min_periods=1).aggregate([np.sum, np.mean])
+    expected_val = np.array([[1, 3.0], [1, 1.5], [3, 7], [3, 3.5]])
+
+    expected_index = MultiIndex.from_tuples(
+        [(0, "sum"), (0, "mean"), (1, "sum"), (1, "mean")]
+    )
+
+    expected_frame = DataFrame(expected_val, index=expected_index, columns=["a", "b"])
+
+    tm.assert_frame_equal(expected_frame, res)
+
+
 def test_rolling_mean_sum_floating_artifacts():
     # GH 42064.
 
@@ -1862,6 +1878,24 @@ def test_rolling_mean_sum_floating_artifacts():
     assert (result[-3:] == 0).all()
 
 
+def test_rolling_agg_when_agg_fail():
+    # GH 46132
+    df = DataFrame({"a": [1, 3], "b": [2, 4]})
+    win = df.rolling(window=2, axis=1, min_periods=1)
+    try:
+        win.aggregate([np.log, np.sqrt])
+    except ValueError:
+        pass
+    tm.assert_frame_equal(win.obj, df)
+    # make sure if aggregate fails the attribute of Rolling/Window will not be changed
+    assert win.axis == 1
+    # make sure the attribute of Rolling/Window will not be changed
+    # when aggregate runs successfully
+    win.aggregate([np.mean, np.sum])
+    tm.assert_frame_equal(win.obj, df)
+    assert win.axis == 1
+
+
 def test_rolling_skew_kurt_floating_artifacts():
     # GH 42064 46431