diff --git a/pandas/core/indexing.py b/pandas/core/indexing.py
index ddae58fd46bb0..750bcac738842 100644
--- a/pandas/core/indexing.py
+++ b/pandas/core/indexing.py
@@ -449,6 +449,38 @@ def loc(self) -> _LocIndexer:
         8          4       5
         9          7       8
 
+        **Set values with a Series**
+
+        Setting column values using a Series aligns along the index values of
+        the Series and DataFrame
+
+        >>> df.loc[:, 'shield'] = pd.Series({7: 8, 8: 10, 9: 13})
+        >>> df
+           max_speed  shield
+        7          1       8
+        8          4       10
+        9          7       13
+
+        Where the index values are not found in the Series index, the values
+        will be NaN
+
+        >>> df.loc[:, 'shield'] = pd.Series({8: 10})
+        >>> df
+           max_speed  shield
+        7          1     NaN
+        8          4    10.0
+        9          7     NaN
+
+        Setting value to Series with a missing index leaves the DataFrame
+        unchanged
+
+        >>> df.loc[:, 'shield'] = pd.Series({11: 14})
+        >>> df
+           max_speed  shield
+        7          1     NaN
+        8          4     NaN
+        9          7     NaN
+
         **Getting values with a MultiIndex**
 
         A number of examples using a DataFrame with a MultiIndex