diff --git a/pandas/_testing/contexts.py b/pandas/_testing/contexts.py
index 5a77c06d65d07..547ec9db20994 100644
--- a/pandas/_testing/contexts.py
+++ b/pandas/_testing/contexts.py
@@ -3,14 +3,13 @@
 from contextlib import contextmanager
 import os
 from pathlib import Path
-import random
 from shutil import rmtree
-import string
 import tempfile
 from typing import (
     IO,
     Any,
 )
+import uuid
 
 import numpy as np
 
@@ -107,9 +106,7 @@ def ensure_clean(filename=None, return_filelike: bool = False, **kwargs: Any):
 
     if filename is None:
         filename = ""
-    filename = (
-        "".join(random.choices(string.ascii_letters + string.digits, k=30)) + filename
-    )
+    filename = str(uuid.uuid4()) + filename
     path = folder / filename
 
     path.touch()
diff --git a/pandas/tests/io/parser/common/test_file_buffer_url.py b/pandas/tests/io/parser/common/test_file_buffer_url.py
index b9ddec0a37c11..fce1d1260b3fe 100644
--- a/pandas/tests/io/parser/common/test_file_buffer_url.py
+++ b/pandas/tests/io/parser/common/test_file_buffer_url.py
@@ -9,6 +9,7 @@
 import os
 import platform
 from urllib.error import URLError
+import uuid
 
 import pytest
 
@@ -87,7 +88,7 @@ def test_nonexistent_path(all_parsers):
     # gh-14086: raise more helpful FileNotFoundError
     # GH#29233 "File foo" instead of "File b'foo'"
     parser = all_parsers
-    path = f"{tm.rands(10)}.csv"
+    path = f"{uuid.uuid4()}.csv"
 
     msg = r"\[Errno 2\]"
     with pytest.raises(FileNotFoundError, match=msg) as e:
@@ -255,7 +256,7 @@ def test_internal_eof_byte_to_file(all_parsers):
     parser = all_parsers
     data = b'c1,c2\r\n"test \x1a    test", test\r\n'
     expected = DataFrame([["test \x1a    test", " test"]], columns=["c1", "c2"])
-    path = f"__{tm.rands(10)}__.csv"
+    path = f"__{uuid.uuid4()}__.csv"
 
     with tm.ensure_clean(path) as path:
         with open(path, "wb") as f:
diff --git a/pandas/tests/io/parser/test_encoding.py b/pandas/tests/io/parser/test_encoding.py
index a70c3ee44edb6..c06ac9e76bd7f 100644
--- a/pandas/tests/io/parser/test_encoding.py
+++ b/pandas/tests/io/parser/test_encoding.py
@@ -2,10 +2,10 @@
 Tests encoding functionality during parsing
 for all of the parsers defined in parsers.py
 """
-
 from io import BytesIO
 import os
 import tempfile
+import uuid
 
 import numpy as np
 import pytest
@@ -54,7 +54,7 @@ def test_utf16_bom_skiprows(all_parsers, sep, encoding):
 4,5,6""".replace(
         ",", sep
     )
-    path = f"__{tm.rands(10)}__.csv"
+    path = f"__{uuid.uuid4()}__.csv"
     kwargs = {"sep": sep, "skiprows": 2}
     utf8 = "utf-8"
 
diff --git a/pandas/tests/io/pytables/conftest.py b/pandas/tests/io/pytables/conftest.py
index 988f78c5ae843..bbd815b9c6309 100644
--- a/pandas/tests/io/pytables/conftest.py
+++ b/pandas/tests/io/pytables/conftest.py
@@ -1,3 +1,5 @@
+import uuid
+
 import pytest
 
 import pandas._testing as tm
@@ -6,7 +8,7 @@
 @pytest.fixture
 def setup_path():
     """Fixture for setup path"""
-    return f"tmp.__{tm.rands(10)}__.h5"
+    return f"tmp.__{uuid.uuid4()}__.h5"
 
 
 @pytest.fixture(scope="module", autouse=True)
diff --git a/pandas/tests/io/test_pickle.py b/pandas/tests/io/test_pickle.py
index 56fc42aa0e2db..3ad8fd4051b48 100644
--- a/pandas/tests/io/test_pickle.py
+++ b/pandas/tests/io/test_pickle.py
@@ -21,6 +21,7 @@
 from pathlib import Path
 import pickle
 import shutil
+import uuid
 from warnings import (
     catch_warnings,
     filterwarnings,
@@ -248,7 +249,7 @@ def test_legacy_sparse_warning(datapath, typ):
 
 @pytest.fixture
 def get_random_path():
-    return f"__{tm.rands(10)}__.pickle"
+    return f"__{uuid.uuid4()}__.pickle"
 
 
 class TestCompression: