diff --git a/pandas/conftest.py b/pandas/conftest.py
index 3803a10e33fae..958df72b3f607 100644
--- a/pandas/conftest.py
+++ b/pandas/conftest.py
@@ -155,7 +155,9 @@ def pytest_collection_modifyitems(items, config):
     # is too short for a specific test, (a) try to make it faster, and (b)
     # if it really is slow add `@settings(deadline=...)` with a working value,
     # or `deadline=None` to entirely disable timeouts for that test.
-    deadline=500,
+    # 2022-02-09: Changed deadline from 500 -> None. Deadline leads to
+    # non-actionable, flaky CI failures (# GH 24641, 44969, 45118, 44969)
+    deadline=None,
     suppress_health_check=(hypothesis.HealthCheck.too_slow,),
 )
 hypothesis.settings.load_profile("ci")
diff --git a/pandas/tests/frame/indexing/test_where.py b/pandas/tests/frame/indexing/test_where.py
index f0d66d040a35c..9b6e04dffa6ce 100644
--- a/pandas/tests/frame/indexing/test_where.py
+++ b/pandas/tests/frame/indexing/test_where.py
@@ -1,9 +1,6 @@
 from datetime import datetime
 
-from hypothesis import (
-    given,
-    settings,
-)
+from hypothesis import given
 import numpy as np
 import pytest
 
@@ -924,7 +921,6 @@ def test_where_nullable_invalid_na(frame_or_series, any_numeric_ea_dtype):
 
 
 @given(data=OPTIONAL_ONE_OF_ALL)
-@settings(deadline=None)  # GH 44969
 def test_where_inplace_casting(data):
     # GH 22051
     df = DataFrame({"a": data})
diff --git a/pandas/tests/io/parser/test_parse_dates.py b/pandas/tests/io/parser/test_parse_dates.py
index 1dfd81366de72..4777bed2a2460 100644
--- a/pandas/tests/io/parser/test_parse_dates.py
+++ b/pandas/tests/io/parser/test_parse_dates.py
@@ -11,10 +11,7 @@
 import warnings
 
 from dateutil.parser import parse as du_parse
-from hypothesis import (
-    given,
-    settings,
-)
+from hypothesis import given
 import numpy as np
 import pytest
 import pytz
@@ -1696,7 +1693,6 @@ def _helper_hypothesis_delimited_date(call, date_string, **kwargs):
 
 @skip_pyarrow
 @given(DATETIME_NO_TZ)
-@settings(deadline=None)
 @pytest.mark.parametrize("delimiter", list(" -./"))
 @pytest.mark.parametrize("dayfirst", [True, False])
 @pytest.mark.parametrize(
diff --git a/pandas/tests/tseries/offsets/test_offsets_properties.py b/pandas/tests/tseries/offsets/test_offsets_properties.py
index 5071c816c313d..1b4fa9292c403 100644
--- a/pandas/tests/tseries/offsets/test_offsets_properties.py
+++ b/pandas/tests/tseries/offsets/test_offsets_properties.py
@@ -10,7 +10,6 @@
 from hypothesis import (
     assume,
     given,
-    settings,
 )
 import pytest
 import pytz
@@ -46,7 +45,6 @@ def test_on_offset_implementations(dt, offset):
 
 
 @given(YQM_OFFSET)
-@settings(deadline=None)  # GH 45118
 def test_shift_across_dst(offset):
     # GH#18319 check that 1) timezone is correctly normalized and
     # 2) that hour is not incorrectly changed by this normalization
diff --git a/pandas/tests/tseries/offsets/test_ticks.py b/pandas/tests/tseries/offsets/test_ticks.py
index 47e7b2aa4d401..7a174b89baa9b 100644
--- a/pandas/tests/tseries/offsets/test_ticks.py
+++ b/pandas/tests/tseries/offsets/test_ticks.py
@@ -10,7 +10,6 @@
     assume,
     example,
     given,
-    settings,
 )
 import numpy as np
 import pytest
@@ -62,7 +61,6 @@ def test_delta_to_tick():
 
 
 @pytest.mark.parametrize("cls", tick_classes)
-@settings(deadline=None)  # GH 24641
 @example(n=2, m=3)
 @example(n=800, m=300)
 @example(n=1000, m=5)
@@ -84,7 +82,6 @@ def test_tick_add_sub(cls, n, m):
 
 @pytest.mark.arm_slow
 @pytest.mark.parametrize("cls", tick_classes)
-@settings(deadline=None)
 @example(n=2, m=3)
 @given(n=INT_NEG_999_TO_POS_999, m=INT_NEG_999_TO_POS_999)
 def test_tick_equality(cls, n, m):