diff --git a/doc/source/whatsnew/v1.5.0.rst b/doc/source/whatsnew/v1.5.0.rst
index 9a6455d4d012f..852d24a3d1c4e 100644
--- a/doc/source/whatsnew/v1.5.0.rst
+++ b/doc/source/whatsnew/v1.5.0.rst
@@ -171,7 +171,7 @@ MultiIndex
 
 I/O
 ^^^
--
+- Bug in :meth:`DataFrame.to_stata` where no error is raised if the :class:`DataFrame` contains ``-np.inf`` (:issue:`45350`)
 -
 
 Period
diff --git a/pandas/io/stata.py b/pandas/io/stata.py
index 4a50a3dabe5e7..e0a070f051534 100644
--- a/pandas/io/stata.py
+++ b/pandas/io/stata.py
@@ -625,12 +625,12 @@ def _cast_to_stata_types(data: DataFrame) -> DataFrame:
                 if data[col].max() >= 2 ** 53 or data[col].min() <= -(2 ** 53):
                     ws = precision_loss_doc.format("int64", "float64")
         elif dtype in (np.float32, np.float64):
-            value = data[col].max()
-            if np.isinf(value):
+            if np.isinf(data[col]).any():
                 raise ValueError(
-                    f"Column {col} has a maximum value of infinity which is outside "
-                    "the range supported by Stata."
+                    f"Column {col} contains infinity or -infinity"
+                    "which is outside the range supported by Stata."
                 )
+            value = data[col].max()
             if dtype == np.float32 and value > float32_max:
                 data[col] = data[col].astype(np.float64)
             elif dtype == np.float64:
diff --git a/pandas/tests/io/test_stata.py b/pandas/tests/io/test_stata.py
index f0fd391c2a9c4..4b6643cfa3903 100644
--- a/pandas/tests/io/test_stata.py
+++ b/pandas/tests/io/test_stata.py
@@ -1473,15 +1473,6 @@ def test_out_of_range_double(self):
             with tm.ensure_clean() as path:
                 df.to_stata(path)
 
-        df.loc[2, "ColumnTooBig"] = np.inf
-        msg = (
-            "Column ColumnTooBig has a maximum value of infinity which is outside "
-            "the range supported by Stata"
-        )
-        with pytest.raises(ValueError, match=msg):
-            with tm.ensure_clean() as path:
-                df.to_stata(path)
-
     def test_out_of_range_float(self):
         original = DataFrame(
             {
@@ -1507,14 +1498,17 @@ def test_out_of_range_float(self):
             original["ColumnTooBig"] = original["ColumnTooBig"].astype(np.float64)
             tm.assert_frame_equal(original, reread.set_index("index"))
 
-        original.loc[2, "ColumnTooBig"] = np.inf
+    @pytest.mark.parametrize("infval", [np.inf, -np.inf])
+    def test_inf(self, infval):
+        # GH 45350
+        df = DataFrame({"WithoutInf": [0.0, 1.0], "WithInf": [2.0, infval]})
         msg = (
-            "Column ColumnTooBig has a maximum value of infinity which "
-            "is outside the range supported by Stata"
+            "Column WithInf contains infinity or -infinity"
+            "which is outside the range supported by Stata."
         )
         with pytest.raises(ValueError, match=msg):
             with tm.ensure_clean() as path:
-                original.to_stata(path)
+                df.to_stata(path)
 
     def test_path_pathlib(self):
         df = tm.makeDataFrame()