diff --git a/.github/workflows/posix.yml b/.github/workflows/posix.yml
index 86c25642f4b2a..135ca0703de8b 100644
--- a/.github/workflows/posix.yml
+++ b/.github/workflows/posix.yml
@@ -33,9 +33,11 @@ jobs:
           [actions-38.yaml, "not slow and not clipboard", "", "", "", "", ""],
           [actions-38.yaml, "slow", "", "", "", "", ""],
           [actions-pypy-38.yaml, "not slow and not clipboard", "", "", "", "", "--max-worker-restart 0"],
-          [actions-39-numpydev.yaml, "not slow and not network", "xsel", "", "", "deprecate", "-W error"],
           [actions-39.yaml, "slow", "", "", "", "", ""],
-          [actions-39.yaml, "not slow and not clipboard", "", "", "", "", ""]
+          [actions-39.yaml, "not slow and not clipboard", "", "", "", "", ""],
+          [actions-310-numpydev.yaml, "not slow and not network", "xclip", "", "", "deprecate", "-W error"],
+          [actions-310.yaml, "not slow and not clipboard", "", "", "", "", ""],
+          [actions-310.yaml, "slow", "", "", "", "", ""],
         ]
       fail-fast: false
     env:
diff --git a/.github/workflows/python-dev.yml b/.github/workflows/python-dev.yml
index 37d8b8474d962..fa1eee2db6fc3 100644
--- a/.github/workflows/python-dev.yml
+++ b/.github/workflows/python-dev.yml
@@ -1,3 +1,11 @@
+# This file is purposely frozen(does not run). DO NOT DELETE IT
+# Unfreeze(by commentingthe if: false() condition) once the
+# next Python Dev version has released beta 1 and both Cython and numpy support it
+# After that Python has released, migrate the workflows to the
+# posix GHA workflows/Azure pipelines and "freeze" this file by
+# uncommenting the if: false() condition
+# Feel free to modify this comment as necessary.
+
 name: Python Dev
 
 on:
@@ -21,13 +29,14 @@ env:
 
 jobs:
   build:
+    if: false # Comment this line out to "unfreeze"
     runs-on: ${{ matrix.os }}
     strategy:
       fail-fast: false
       matrix:
         os: [ubuntu-latest, macOS-latest, windows-latest]
 
-    name: actions-310-dev
+    name: actions-311-dev
     timeout-minutes: 80
 
     concurrency:
@@ -43,7 +52,7 @@ jobs:
     - name: Set up Python Dev Version
       uses: actions/setup-python@v2
       with:
-        python-version: '3.10-dev'
+        python-version: '3.11-dev'
 
     # TODO: GH#44980 https://github.com/pypa/setuptools/issues/2941
     - name: Install dependencies
diff --git a/ci/azure/posix.yml b/ci/azure/posix.yml
index b7c36bb87353b..02a4a9ad44865 100644
--- a/ci/azure/posix.yml
+++ b/ci/azure/posix.yml
@@ -18,6 +18,26 @@ jobs:
         CONDA_PY: "38"
         PATTERN: "not slow"
         PYTEST_TARGET: "pandas/tests/[i-z]*"
+      py39_macos_1:
+        ENV_FILE: ci/deps/azure-macos-39.yaml
+        CONDA_PY: "39"
+        PATTERN: "not slow"
+        PYTEST_TARGET: "pandas/tests/[a-h]*"
+      py39_macos_2:
+        ENV_FILE: ci/deps/azure-macos-39.yaml
+        CONDA_PY: "39"
+        PATTERN: "not slow"
+        PYTEST_TARGET: "pandas/tests/[i-z]*"
+      py310_macos_1:
+        ENV_FILE: ci/deps/azure-macos-310.yaml
+        CONDA_PY: "310"
+        PATTERN: "not slow"
+        PYTEST_TARGET: "pandas/tests/[a-h]*"
+      py310_macos_2:
+        ENV_FILE: ci/deps/azure-macos-310.yaml
+        CONDA_PY: "310"
+        PATTERN: "not slow"
+        PYTEST_TARGET: "pandas/tests/[i-z]*"
 
   steps:
     - script: echo '##vso[task.prependpath]$(HOME)/miniconda3/bin'
diff --git a/ci/azure/windows.yml b/ci/azure/windows.yml
index 7f3efb5a4dbf3..7061a266f28c7 100644
--- a/ci/azure/windows.yml
+++ b/ci/azure/windows.yml
@@ -36,6 +36,20 @@ jobs:
         PYTEST_WORKERS: 2  # GH-42236
         PYTEST_TARGET: "pandas/tests/[i-z]*"
 
+      py310_1:
+        ENV_FILE: ci/deps/azure-windows-310.yaml
+        CONDA_PY: "310"
+        PATTERN: "not slow and not high_memory"
+        PYTEST_WORKERS: 2  # GH-42236
+        PYTEST_TARGET: "pandas/tests/[a-h]*"
+
+      py310_2:
+        ENV_FILE: ci/deps/azure-windows-310.yaml
+        CONDA_PY: "310"
+        PATTERN: "not slow and not high_memory"
+        PYTEST_WORKERS: 2  # GH-42236
+        PYTEST_TARGET: "pandas/tests/[i-z]*"
+
   steps:
     - powershell: |
         Write-Host "##vso[task.prependpath]$env:CONDA\Scripts"
diff --git a/ci/deps/actions-39-numpydev.yaml b/ci/deps/actions-310-numpydev.yaml
similarity index 95%
rename from ci/deps/actions-39-numpydev.yaml
rename to ci/deps/actions-310-numpydev.yaml
index 4a6acf55e265f..3e32665d5433f 100644
--- a/ci/deps/actions-39-numpydev.yaml
+++ b/ci/deps/actions-310-numpydev.yaml
@@ -2,7 +2,7 @@ name: pandas-dev
 channels:
   - defaults
 dependencies:
-  - python=3.9
+  - python=3.10
 
   # tools
   - pytest>=6.0
diff --git a/ci/deps/actions-310.yaml b/ci/deps/actions-310.yaml
new file mode 100644
index 0000000000000..9829380620f86
--- /dev/null
+++ b/ci/deps/actions-310.yaml
@@ -0,0 +1,51 @@
+name: pandas-dev
+channels:
+  - conda-forge
+dependencies:
+  - python=3.9
+
+  # test dependencies
+  - cython=0.29.24
+  - pytest>=6.0
+  - pytest-cov
+  - pytest-xdist>=1.31
+  - hypothesis>=5.5.3
+  - psutil
+
+  # required dependencies
+  - python-dateutil
+  - numpy
+  - pytz
+
+  # optional dependencies
+  - beautifulsoup4
+  - blosc
+  - bottleneck
+  - fastparquet
+  - fsspec
+  - html5lib
+  - gcsfs
+  - jinja2
+  - lxml
+  - matplotlib
+  # TODO: uncomment after numba supports py310
+  #- numba
+  - numexpr
+  - openpyxl
+  - odfpy
+  - pandas-gbq
+  - psycopg2
+  - pymysql
+  - pytables
+  - pyarrow
+  - pyreadstat
+  - pyxlsb
+  - s3fs
+  - scipy
+  - sqlalchemy
+  - tabulate
+  - xarray
+  - xlrd
+  - xlsxwriter
+  - xlwt
+  - zstandard
diff --git a/ci/deps/azure-macos-310.yaml b/ci/deps/azure-macos-310.yaml
new file mode 100644
index 0000000000000..312fac8091db6
--- /dev/null
+++ b/ci/deps/azure-macos-310.yaml
@@ -0,0 +1,36 @@
+name: pandas-dev
+channels:
+  - defaults
+  - conda-forge
+dependencies:
+  - python=3.10
+
+  # tools
+  - cython>=0.29.24
+  - pytest>=6.0
+  - pytest-xdist>=1.31
+  - hypothesis>=5.5.3
+  - pytest-azurepipelines
+
+  # pandas dependencies
+  - beautifulsoup4
+  - bottleneck
+  - html5lib
+  - jinja2
+  - lxml
+  - matplotlib
+  - nomkl
+  - numexpr
+  - numpy
+  - openpyxl
+  - pyarrow
+  - pyreadstat
+  - pytables
+  - python-dateutil==2.8.1
+  - pytz
+  - pyxlsb
+  - xarray
+  - xlrd
+  - xlsxwriter
+  - xlwt
+  - zstandard
diff --git a/ci/deps/azure-macos-38.yaml b/ci/deps/azure-macos-38.yaml
index 472dc8754d13e..422aa86c57fc7 100644
--- a/ci/deps/azure-macos-38.yaml
+++ b/ci/deps/azure-macos-38.yaml
@@ -6,6 +6,7 @@ dependencies:
   - python=3.8
 
   # tools
+  - cython>=0.29.24
   - pytest>=6.0
   - pytest-xdist>=1.31
   - hypothesis>=5.5.3
@@ -33,6 +34,3 @@ dependencies:
   - xlsxwriter
   - xlwt
   - zstandard
-  - pip
-  - pip:
-    - cython>=0.29.24
diff --git a/ci/deps/azure-macos-39.yaml b/ci/deps/azure-macos-39.yaml
new file mode 100644
index 0000000000000..a0860ef536953
--- /dev/null
+++ b/ci/deps/azure-macos-39.yaml
@@ -0,0 +1,36 @@
+name: pandas-dev
+channels:
+  - defaults
+  - conda-forge
+dependencies:
+  - python=3.9
+
+  # tools
+  - cython>=0.29.24
+  - pytest>=6.0
+  - pytest-xdist>=1.31
+  - hypothesis>=5.5.3
+  - pytest-azurepipelines
+
+  # pandas dependencies
+  - beautifulsoup4
+  - bottleneck
+  - html5lib
+  - jinja2
+  - lxml
+  - matplotlib=3.3.2
+  - nomkl
+  - numexpr
+  - numpy=1.21.3
+  - openpyxl
+  - pyarrow=1.0.1
+  - pyreadstat
+  - pytables
+  - python-dateutil==2.8.1
+  - pytz
+  - pyxlsb
+  - xarray
+  - xlrd
+  - xlsxwriter
+  - xlwt
+  - zstandard
diff --git a/ci/deps/azure-windows-310.yaml b/ci/deps/azure-windows-310.yaml
new file mode 100644
index 0000000000000..8e6f4deef6057
--- /dev/null
+++ b/ci/deps/azure-windows-310.yaml
@@ -0,0 +1,41 @@
+name: pandas-dev
+channels:
+  - conda-forge
+  - defaults
+dependencies:
+  - python=3.10
+
+  # tools
+  - cython>=0.29.24
+  - pytest>=6.0
+  - pytest-xdist>=1.31
+  - hypothesis>=5.5.3
+  - pytest-azurepipelines
+
+  # pandas dependencies
+  - beautifulsoup4
+  - bottleneck
+  - fsspec>=0.8.0
+  - gcsfs
+  - html5lib
+  - jinja2
+  - lxml
+  - matplotlib
+  # TODO: uncomment after numba supports py310
+  #- numba
+  - numexpr
+  - numpy
+  - openpyxl
+  - pyarrow
+  - pytables
+  - python-dateutil
+  - pytz
+  - s3fs>=0.4.2
+  - scipy
+  - sqlalchemy
+  - xlrd
+  - xlsxwriter
+  - xlwt
+  - pyreadstat
+  - pyxlsb
+  - zstandard
diff --git a/pandas/tests/plotting/frame/test_frame.py b/pandas/tests/plotting/frame/test_frame.py
index 6c07366e402d6..ff247349ff4d5 100644
--- a/pandas/tests/plotting/frame/test_frame.py
+++ b/pandas/tests/plotting/frame/test_frame.py
@@ -682,7 +682,7 @@ def test_raise_error_on_datetime_time_data(self):
         # GH 8113, datetime.time type is not supported by matplotlib in scatter
         df = DataFrame(np.random.randn(10), columns=["a"])
         df["dtime"] = date_range(start="2014-01-01", freq="h", periods=10).time
-        msg = "must be a string or a number, not 'datetime.time'"
+        msg = "must be a string or a (real )?number, not 'datetime.time'"
 
         with pytest.raises(TypeError, match=msg):
             df.plot(kind="scatter", x="dtime", y="a")