diff --git a/doc/source/whatsnew/v1.4.0.rst b/doc/source/whatsnew/v1.4.0.rst
index d6ad5eb2003ce..a9d697adc301f 100644
--- a/doc/source/whatsnew/v1.4.0.rst
+++ b/doc/source/whatsnew/v1.4.0.rst
@@ -528,6 +528,7 @@ I/O
 - Bug in :func:`read_json` not handling non-numpy dtypes correctly (especially ``category``) (:issue:`21892`, :issue:`33205`)
 - Bug in :func:`json_normalize` where multi-character ``sep`` parameter is incorrectly prefixed to every key (:issue:`43831`)
 - Bug in :func:`read_csv` with :code:`float_precision="round_trip"` which did not skip initial/trailing whitespace (:issue:`43713`)
+- Bug in dumping/loading a :class:`DataFrame` with ``yaml.dump(frame)`` (:issue:`42748`)
 -
 
 Period
diff --git a/pandas/_libs/internals.pyx b/pandas/_libs/internals.pyx
index 78853ce6e41dc..957432df20395 100644
--- a/pandas/_libs/internals.pyx
+++ b/pandas/_libs/internals.pyx
@@ -565,6 +565,14 @@ cpdef update_blklocs_and_blknos(
     return new_blklocs, new_blknos
 
 
+def _unpickle_block(values, placement, ndim):
+    # We have to do some gymnastics b/c "ndim" is keyword-only
+
+    from pandas.core.internals.blocks import new_block
+
+    return new_block(values, placement, ndim=ndim)
+
+
 @cython.freelist(64)
 cdef class SharedBlock:
     """
@@ -588,14 +596,8 @@ cdef class SharedBlock:
         self.ndim = ndim
 
     cpdef __reduce__(self):
-        # We have to do some gymnastics b/c "ndim" is keyword-only
-        from functools import partial
-
-        from pandas.core.internals.blocks import new_block
-
-        args = (self.values, self.mgr_locs.indexer)
-        func = partial(new_block, ndim=self.ndim)
-        return func, args
+        args = (self.values, self.mgr_locs.indexer, self.ndim)
+        return _unpickle_block, args
 
     cpdef __setstate__(self, state):
         from pandas.core.construction import extract_array
diff --git a/pandas/core/internals/array_manager.py b/pandas/core/internals/array_manager.py
index 583a22d09b110..9344aea8221d5 100644
--- a/pandas/core/internals/array_manager.py
+++ b/pandas/core/internals/array_manager.py
@@ -170,7 +170,12 @@ def set_axis(self, axis: int, new_labels: Index) -> None:
     def get_dtypes(self):
         return np.array([arr.dtype for arr in self.arrays], dtype="object")
 
-    # TODO setstate getstate
+    def __getstate__(self):
+        return self.arrays, self._axes
+
+    def __setstate__(self, state):
+        self.arrays = state[0]
+        self._axes = state[1]
 
     def __repr__(self) -> str:
         output = type(self).__name__
diff --git a/pandas/tests/test_downstream.py b/pandas/tests/test_downstream.py
index a8b05e3178197..f927a0ec0927b 100644
--- a/pandas/tests/test_downstream.py
+++ b/pandas/tests/test_downstream.py
@@ -167,6 +167,19 @@ def test_pyarrow(df):
     tm.assert_frame_equal(result, df)
 
 
+def test_yaml_dump(df):
+    # GH#42748
+    yaml = import_module("yaml")
+
+    dumped = yaml.dump(df)
+
+    loaded = yaml.load(dumped, Loader=yaml.Loader)
+    tm.assert_frame_equal(df, loaded)
+
+    loaded2 = yaml.load(dumped, Loader=yaml.UnsafeLoader)
+    tm.assert_frame_equal(df, loaded2)
+
+
 def test_missing_required_dependency():
     # GH 23868
     # To ensure proper isolation, we pass these flags