diff --git a/doc/source/user_guide/options.rst b/doc/source/user_guide/options.rst
index c415616affcd5..00da304ec9516 100644
--- a/doc/source/user_guide/options.rst
+++ b/doc/source/user_guide/options.rst
@@ -499,6 +499,9 @@ styler.format.thousands                 None         String representation for t
                                                      integers, and floating point and complex numbers.
 styler.format.escape                    None         Whether to escape "html" or "latex" special
                                                      characters in the display representation.
+styler.html.mathjax                     True         If set to False will render specific CSS classes to
+                                                     table attributes that will prevent Mathjax from rendering
+                                                     in Jupyter Notebook.
 ======================================= ============ ==================================
 
 
diff --git a/doc/source/whatsnew/v1.4.0.rst b/doc/source/whatsnew/v1.4.0.rst
index aef6128c63829..bb594b896d55e 100644
--- a/doc/source/whatsnew/v1.4.0.rst
+++ b/doc/source/whatsnew/v1.4.0.rst
@@ -75,7 +75,9 @@ Styler
   - :meth:`.Styler.to_latex` introduces keyword argument ``environment``, which also allows a specific "longtable" entry through a separate jinja2 template (:issue:`41866`).
   - :meth:`.Styler.to_html` introduces keyword arguments ``sparse_index`` and ``sparse_columns`` (:issue:`41946`)
   - Keyword argument ``level`` is added to :meth:`.Styler.hide_index` and :meth:`.Styler.hide_columns` for optionally controlling hidden levels in a MultiIndex (:issue:`25475`)
-  - Global options have been extended to configure default ``Styler`` properties including formatting and encoding options (:issue:`41395`)
+  - Global options have been extended to configure default ``Styler`` properties including formatting and encoding and mathjax options (:issue:`41395`)
+
+Formerly Styler relied on ``display.html.use_mathjax``, which has now been replaced by ``styler.html.mathjax``.
 
 There are also bug fixes and deprecations listed below.
 
diff --git a/pandas/core/config_init.py b/pandas/core/config_init.py
index a6aa285f538d3..cbe75e914981b 100644
--- a/pandas/core/config_init.py
+++ b/pandas/core/config_init.py
@@ -798,11 +798,17 @@ def register_converter_cb(key):
     The encoding used for output HTML and LaTeX files.
 """
 
+styler_mathjax = """
+: bool
+    If False will render special CSS classes to table attributes that indicate Mathjax
+    will not be used in Jupyter Notebook.
+"""
+
 with cf.config_prefix("styler"):
-    cf.register_option("sparse.index", True, styler_sparse_index_doc, validator=bool)
+    cf.register_option("sparse.index", True, styler_sparse_index_doc, validator=is_bool)
 
     cf.register_option(
-        "sparse.columns", True, styler_sparse_columns_doc, validator=bool
+        "sparse.columns", True, styler_sparse_columns_doc, validator=is_bool
     )
 
     cf.register_option(
@@ -847,3 +853,5 @@ def register_converter_cb(key):
         styler_formatter,
         validator=is_instance_factory([type(None), dict, callable, str]),
     )
+
+    cf.register_option("html.mathjax", True, styler_mathjax, validator=is_bool)
diff --git a/pandas/io/formats/style_render.py b/pandas/io/formats/style_render.py
index f51a1f5d9809d..370abe715185b 100644
--- a/pandas/io/formats/style_render.py
+++ b/pandas/io/formats/style_render.py
@@ -250,8 +250,7 @@ def _translate(self, sparse_index: bool, sparse_cols: bool, blank: str = " 
             d.update({k: map})
 
         table_attr = self.table_attributes
-        use_mathjax = get_option("display.html.use_mathjax")
-        if not use_mathjax:
+        if not get_option("styler.html.mathjax"):
             table_attr = table_attr or ""
             if 'class="' in table_attr:
                 table_attr = table_attr.replace('class="', 'class="tex2jax_ignore ')
diff --git a/pandas/tests/io/formats/style/test_style.py b/pandas/tests/io/formats/style/test_style.py
index dc8be68532f0e..011730cca8136 100644
--- a/pandas/tests/io/formats/style/test_style.py
+++ b/pandas/tests/io/formats/style/test_style.py
@@ -402,10 +402,10 @@ def test_repr_html_ok(self):
         self.styler._repr_html_()
 
     def test_repr_html_mathjax(self):
-        # gh-19824
+        # gh-19824 / 41395
         assert "tex2jax_ignore" not in self.styler._repr_html_()
 
-        with pd.option_context("display.html.use_mathjax", False):
+        with pd.option_context("styler.html.mathjax", False):
             assert "tex2jax_ignore" in self.styler._repr_html_()
 
     def test_update_ctx(self):