diff --git a/pandas/_typing.py b/pandas/_typing.py
index 9c20eb12dc7fc..68ec331c2781f 100644
--- a/pandas/_typing.py
+++ b/pandas/_typing.py
@@ -111,7 +111,7 @@
 IndexLabel = Union[Hashable, Sequence[Hashable]]
 Level = Union[Hashable, int]
 Shape = Tuple[int, ...]
-Suffixes = Tuple[str, str]
+Suffixes = Tuple[Optional[str], Optional[str]]
 Ordered = Optional[bool]
 JSONSerializable = Optional[Union[PythonScalar, List, Dict]]
 Frequency = Union[str, "DateOffset"]