diff --git a/pandas/tests/indexes/numeric/test_numeric.py b/pandas/tests/indexes/numeric/test_numeric.py
index 9572aeaf41c91..de75f1dffde56 100644
--- a/pandas/tests/indexes/numeric/test_numeric.py
+++ b/pandas/tests/indexes/numeric/test_numeric.py
@@ -2,6 +2,10 @@
 import pytest
 
 from pandas._libs.tslibs import Timestamp
+from pandas.compat import (
+    is_platform_arm,
+    is_platform_mac,
+)
 
 import pandas as pd
 from pandas import (
@@ -531,7 +535,10 @@ def test_constructor(self, dtype):
         res = Index([1, 2 ** 63 + 1], dtype=dtype)
         tm.assert_index_equal(res, idx)
 
-    @pytest.mark.xfail(reason="https://github.com/numpy/numpy/issues/19146")
+    @pytest.mark.xfail(
+        not (is_platform_arm and is_platform_mac()),
+        reason="https://github.com/numpy/numpy/issues/19146",
+    )
     def test_constructor_does_not_cast_to_float(self):
         # https://github.com/numpy/numpy/issues/19146
         values = [0, np.iinfo(np.uint64).max]
diff --git a/pandas/tests/window/test_rolling.py b/pandas/tests/window/test_rolling.py
index 17a6d9216ca92..77ca482936298 100644
--- a/pandas/tests/window/test_rolling.py
+++ b/pandas/tests/window/test_rolling.py
@@ -6,7 +6,10 @@
 import numpy as np
 import pytest
 
-from pandas.compat import is_platform_arm
+from pandas.compat import (
+    is_platform_arm,
+    is_platform_mac,
+)
 from pandas.errors import UnsupportedFunctionCall
 
 from pandas import (
@@ -1073,7 +1076,7 @@ def test_rolling_sem(frame_or_series):
     tm.assert_series_equal(result, expected)
 
 
-@pytest.mark.xfail(is_platform_arm(), reason="GH 41740")
+@pytest.mark.xfail(is_platform_arm() and not is_platform_mac(), reason="GH 38921")
 @pytest.mark.parametrize(
     ("func", "third_value", "values"),
     [