diff --git a/pandas/_typing.py b/pandas/_typing.py
index 7c74fc54b8d67..d6561176deb71 100644
--- a/pandas/_typing.py
+++ b/pandas/_typing.py
@@ -187,3 +187,14 @@
 # internals
 Manager = Union["ArrayManager", "BlockManager"]
 SingleManager = Union["SingleArrayManager", "SingleBlockManager"]
+
+# indexing
+# PositionalIndexer -> valid 1D positional indexer, e.g. can pass
+# to ndarray.__getitem__
+# TODO: add Ellipsis, see
+# https://github.com/python/typing/issues/684#issuecomment-548203158
+# https://bugs.python.org/issue41810
+PositionalIndexer = Union[int, np.integer, slice, Sequence[int], np.ndarray]
+PositionalIndexer2D = Union[
+    PositionalIndexer, Tuple[PositionalIndexer, PositionalIndexer]
+]
diff --git a/pandas/core/arrays/_mixins.py b/pandas/core/arrays/_mixins.py
index 0b208d4f2ab72..d4e5ca00b06dd 100644
--- a/pandas/core/arrays/_mixins.py
+++ b/pandas/core/arrays/_mixins.py
@@ -13,6 +13,7 @@
 from pandas._libs import lib
 from pandas._typing import (
     F,
+    PositionalIndexer2D,
     Shape,
 )
 from pandas.compat.numpy import function as nv
@@ -274,7 +275,8 @@ def _validate_setitem_value(self, value):
         return value
 
     def __getitem__(
-        self: NDArrayBackedExtensionArrayT, key: int | slice | np.ndarray
+        self: NDArrayBackedExtensionArrayT,
+        key: PositionalIndexer2D,
     ) -> NDArrayBackedExtensionArrayT | Any:
         if lib.is_integer(key):
             # fast-path
diff --git a/pandas/core/arrays/base.py b/pandas/core/arrays/base.py
index ac3ae6407305c..933b829e0b29f 100644
--- a/pandas/core/arrays/base.py
+++ b/pandas/core/arrays/base.py
@@ -24,6 +24,7 @@
 from pandas._typing import (
     ArrayLike,
     Dtype,
+    PositionalIndexer,
     Shape,
 )
 from pandas.compat import set_function_name
@@ -288,7 +289,7 @@ def _from_factorized(cls, values, original):
     # Must be a Sequence
     # ------------------------------------------------------------------------
 
-    def __getitem__(self, item: int | slice | np.ndarray) -> ExtensionArray | Any:
+    def __getitem__(self, item: PositionalIndexer) -> ExtensionArray | Any:
         """
         Select a subset of self.
 
diff --git a/pandas/core/arrays/datetimelike.py b/pandas/core/arrays/datetimelike.py
index 2e7f18965d2b2..b039df12ee3df 100644
--- a/pandas/core/arrays/datetimelike.py
+++ b/pandas/core/arrays/datetimelike.py
@@ -47,6 +47,7 @@
     Dtype,
     DtypeObj,
     NpDtype,
+    PositionalIndexer2D,
 )
 from pandas.compat.numpy import function as nv
 from pandas.errors import (
@@ -338,7 +339,7 @@ def __array__(self, dtype: NpDtype | None = None) -> np.ndarray:
         return self._ndarray
 
     def __getitem__(
-        self, key: int | slice | np.ndarray
+        self, key: PositionalIndexer2D
     ) -> DatetimeLikeArrayMixin | DTScalarOrNaT:
         """
         This getitem defers to the underlying array, which by-definition can
diff --git a/pandas/core/arrays/masked.py b/pandas/core/arrays/masked.py
index 92bd031aec3a7..93de1cd91d625 100644
--- a/pandas/core/arrays/masked.py
+++ b/pandas/core/arrays/masked.py
@@ -17,6 +17,7 @@
     ArrayLike,
     Dtype,
     NpDtype,
+    PositionalIndexer,
     Scalar,
     type_t,
 )
@@ -134,7 +135,7 @@ def __init__(self, values: np.ndarray, mask: np.ndarray, copy: bool = False):
     def dtype(self) -> BaseMaskedDtype:
         raise AbstractMethodError(self)
 
-    def __getitem__(self, item: int | slice | np.ndarray) -> BaseMaskedArray | Any:
+    def __getitem__(self, item: PositionalIndexer) -> BaseMaskedArray | Any:
         if is_integer(item):
             if self._mask[item]:
                 return self.dtype.na_value
diff --git a/pandas/core/arrays/string_arrow.py b/pandas/core/arrays/string_arrow.py
index 77f01f895a667..faca868873efa 100644
--- a/pandas/core/arrays/string_arrow.py
+++ b/pandas/core/arrays/string_arrow.py
@@ -17,6 +17,7 @@
 from pandas._typing import (
     Dtype,
     NpDtype,
+    PositionalIndexer,
     type_t,
 )
 from pandas.util._decorators import doc
@@ -310,7 +311,7 @@ def _concat_same_type(cls, to_concat) -> ArrowStringArray:
             )
         )
 
-    def __getitem__(self, item: Any) -> Any:
+    def __getitem__(self, item: PositionalIndexer) -> Any:
         """Select a subset of self.
 
         Parameters
diff --git a/pandas/core/internals/blocks.py b/pandas/core/internals/blocks.py
index 5529f9f430375..90b5366b1a23e 100644
--- a/pandas/core/internals/blocks.py
+++ b/pandas/core/internals/blocks.py
@@ -1381,9 +1381,7 @@ def iget(self, col):
             elif isinstance(col, slice):
                 if col != slice(None):
                     raise NotImplementedError(col)
-                # error: Invalid index type "List[Any]" for "ExtensionArray"; expected
-                # type "Union[int, slice, ndarray]"
-                return self.values[[loc]]  # type: ignore[index]
+                return self.values[[loc]]
             return self.values[loc]
         else:
             if col != 0: