diff --git a/ci/deps/actions-37-db.yaml b/ci/deps/actions-37-db.yaml
index 5381caaa242cf..8755e1a02c3cf 100644
--- a/ci/deps/actions-37-db.yaml
+++ b/ci/deps/actions-37-db.yaml
@@ -32,7 +32,7 @@ dependencies:
   - google-cloud-bigquery>=1.27.2 # GH 36436
   - psycopg2
   - pyarrow>=0.15.0
-  - pymysql<0.10.0 # temporary pin, GH 36465
+  - pymysql
   - pytables
   - python-snappy
   - python-dateutil
diff --git a/doc/source/whatsnew/v1.3.0.rst b/doc/source/whatsnew/v1.3.0.rst
index 3a0e1b7568c91..6482f8bf8d6d9 100644
--- a/doc/source/whatsnew/v1.3.0.rst
+++ b/doc/source/whatsnew/v1.3.0.rst
@@ -486,7 +486,7 @@ Optional libraries below the lowest tested version may still work, but are not c
 +-----------------+-----------------+---------+
 | pyarrow         | 0.15.0          |         |
 +-----------------+-----------------+---------+
-| pymysql         | 0.7.11          |         |
+| pymysql         | 0.8.1           |    X    |
 +-----------------+-----------------+---------+
 | pytables        | 3.5.1           |         |
 +-----------------+-----------------+---------+
diff --git a/pandas/io/sql.py b/pandas/io/sql.py
index 4b5baa0a18c90..4a83814c52ade 100644
--- a/pandas/io/sql.py
+++ b/pandas/io/sql.py
@@ -1592,18 +1592,13 @@ def to_sql(
         )
         table.create()
 
-        from sqlalchemy import exc
+        from sqlalchemy.exc import SQLAlchemyError
 
         try:
             table.insert(chunksize, method=method)
-        except exc.SQLAlchemyError as err:
-            # GH34431
-            msg = "(1054, \"Unknown column 'inf' in 'field list'\")"
-            err_text = str(err.orig)
-            if re.search(msg, err_text):
-                raise ValueError("inf cannot be used with MySQL") from err
-            else:
-                raise err
+        except SQLAlchemyError as err:
+            # GH 34431 36465
+            raise ValueError("inf cannot be used with MySQL") from err
 
         if not name.isdigit() and not name.islower():
             # check for potentially case sensitivity issues (GH7815)
diff --git a/pandas/tests/io/test_sql.py b/pandas/tests/io/test_sql.py
index c90f6ef956a65..04ddef57a9621 100644
--- a/pandas/tests/io/test_sql.py
+++ b/pandas/tests/io/test_sql.py
@@ -2007,12 +2007,22 @@ def main(connectable):
         "input",
         [{"foo": [np.inf]}, {"foo": [-np.inf]}, {"foo": [-np.inf], "infe0": ["bar"]}],
     )
-    def test_to_sql_with_negative_npinf(self, input):
+    def test_to_sql_with_negative_npinf(self, input, request):
         # GH 34431
 
         df = DataFrame(input)
 
         if self.flavor == "mysql":
+            # GH 36465
+            # The input {"foo": [-np.inf], "infe0": ["bar"]} does not raise any error
+            # for pymysql version >= 0.10
+            # TODO: remove this version check after GH 36465 is fixed
+            import pymysql
+
+            if pymysql.VERSION[0:3] >= (0, 10, 0) and "infe0" in df.columns:
+                mark = pytest.mark.xfail(reason="GH 36465")
+                request.node.add_marker(mark)
+
             msg = "inf cannot be used with MySQL"
             with pytest.raises(ValueError, match=msg):
                 df.to_sql("foobar", self.conn, index=False)