diff --git a/pandas/tests/io/formats/style/test_tooltip.py b/pandas/tests/io/formats/style/test_tooltip.py
index 9539780287f15..71ce496cca030 100644
--- a/pandas/tests/io/formats/style/test_tooltip.py
+++ b/pandas/tests/io/formats/style/test_tooltip.py
@@ -7,99 +7,79 @@
 from pandas.io.formats.style import Styler
 
 
-class TestStylerTooltip:
-    @pytest.mark.parametrize(
-        "ttips",
-        [
-            DataFrame(
-                data=[["Min", "Max"], [np.nan, ""]],
-                columns=["A", "B"],
-                index=["a", "b"],
-            ),
-            DataFrame(data=[["Max", "Min"]], columns=["B", "A"], index=["a"]),
-            DataFrame(
-                data=[["Min", "Max", None]], columns=["A", "B", "C"], index=["a"]
-            ),
-        ],
+@pytest.fixture
+def df():
+    return DataFrame(
+        data=[[0, 1, 2], [3, 4, 5], [6, 7, 8]],
+        columns=["A", "B", "C"],
+        index=["x", "y", "z"],
     )
-    def test_tooltip_render(self, ttips):
-        # GH 21266
-        df = DataFrame(data=[[0, 3], [1, 2]], columns=["A", "B"], index=["a", "b"])
-        s = Styler(df, uuid_len=0).set_tooltips(ttips).render()
-
-        # test tooltip table level class
-        assert "#T__ .pd-t {\n  visibility: hidden;\n" in s
-
-        # test 'Min' tooltip added
-        assert (
-            "#T__ #T__row0_col0:hover .pd-t {\n  visibility: visible;\n}\n"
-            + '#T__ #T__row0_col0 .pd-t::after {\n  content: "Min";\n}'
-            in s
-        )
-        assert (
-            '<td id="T__row0_col0" class="data row0 col0" >0<span class="pd-t">'
-            + "</span></td>"
-            in s
-        )
-
-        # test 'Max' tooltip added
-        assert (
-            "#T__ #T__row0_col1:hover .pd-t {\n  visibility: visible;\n}\n"
-            + '#T__ #T__row0_col1 .pd-t::after {\n  content: "Max";\n}'
-            in s
-        )
-        assert (
-            '<td id="T__row0_col1" class="data row0 col1" >3<span class="pd-t">'
-            + "</span></td>"
-            in s
-        )
-
-    def test_tooltip_reindex(self):
-        # GH 39317
-        df = DataFrame(
-            data=[[0, 1, 2], [3, 4, 5], [6, 7, 8]], columns=[0, 1, 2], index=[0, 1, 2]
-        )
-        ttips = DataFrame(
-            data=[["Mi", "Ma"], ["Mu", "Mo"]],
-            columns=[0, 2],
-            index=[0, 2],
-        )
-        s = Styler(df, uuid_len=0).set_tooltips(DataFrame(ttips)).render()
-        assert '#T__ #T__row0_col0 .pd-t::after {\n  content: "Mi";\n}' in s
-        assert '#T__ #T__row0_col2 .pd-t::after {\n  content: "Ma";\n}' in s
-        assert '#T__ #T__row2_col0 .pd-t::after {\n  content: "Mu";\n}' in s
-        assert '#T__ #T__row2_col2 .pd-t::after {\n  content: "Mo";\n}' in s
-
-    def test_tooltip_ignored(self):
-        # GH 21266
-        df = DataFrame(data=[[0, 1], [2, 3]])
-        s = Styler(df).render()  # no set_tooltips() creates no <span>
-        assert '<style type="text/css">\n</style>' in s
-        assert '<span class="pd-t"></span>' not in s
-
-    def test_tooltip_css_class(self):
-        # GH 21266
-        df = DataFrame(data=[[0, 1], [2, 3]])
-        s = (
-            Styler(df, uuid_len=0)
-            .set_tooltips(
-                DataFrame([["tooltip"]]),
-                css_class="other-class",
-                props=[("color", "green")],
-            )
-            .render()
-        )
-        assert "#T__ .other-class {\n  color: green;\n" in s
-        assert '#T__ #T__row0_col0 .other-class::after {\n  content: "tooltip";\n' in s
-
-        # GH 39563
-        s = (
-            Styler(df, uuid_len=0)
-            .set_tooltips(
-                DataFrame([["tooltip"]]),
-                css_class="other-class",
-                props="color:green;color:red;",
-            )
-            .render()
-        )
-        assert "#T__ .other-class {\n  color: green;\n  color: red;\n}" in s
+
+
+@pytest.fixture
+def styler(df):
+    return Styler(df, uuid_len=0)
+
+
+@pytest.mark.parametrize(
+    "ttips",
+    [
+        DataFrame(  # Test basic reindex and ignoring blank
+            data=[["Min", "Max"], [np.nan, ""]],
+            columns=["A", "C"],
+            index=["x", "y"],
+        ),
+        DataFrame(  # Test non-referenced columns, reversed col names, short index
+            data=[["Max", "Min", "Bad-Col"]], columns=["C", "A", "D"], index=["x"]
+        ),
+    ],
+)
+def test_tooltip_render(ttips, styler):
+    # GH 21266
+    result = styler.set_tooltips(ttips).render()
+
+    # test tooltip table level class
+    assert "#T__ .pd-t {\n  visibility: hidden;\n" in result
+
+    # test 'Min' tooltip added
+    assert "#T__ #T__row0_col0:hover .pd-t {\n  visibility: visible;\n}" in result
+    assert '#T__ #T__row0_col0 .pd-t::after {\n  content: "Min";\n}' in result
+    assert 'class="data row0 col0" >0<span class="pd-t"></span></td>' in result
+
+    # test 'Max' tooltip added
+    assert "#T__ #T__row0_col2:hover .pd-t {\n  visibility: visible;\n}" in result
+    assert '#T__ #T__row0_col2 .pd-t::after {\n  content: "Max";\n}' in result
+    assert 'class="data row0 col2" >2<span class="pd-t"></span></td>' in result
+
+    # test Nan, empty string and bad column ignored
+    assert "#T__ #T__row1_col0:hover .pd-t {\n  visibility: visible;\n}" not in result
+    assert "#T__ #T__row1_col1:hover .pd-t {\n  visibility: visible;\n}" not in result
+    assert "#T__ #T__row0_col1:hover .pd-t {\n  visibility: visible;\n}" not in result
+    assert "#T__ #T__row1_col2:hover .pd-t {\n  visibility: visible;\n}" not in result
+    assert "Bad-Col" not in result
+
+
+def test_tooltip_ignored(styler):
+    # GH 21266
+    result = styler.render()  # no set_tooltips() creates no <span>
+    assert '<style type="text/css">\n</style>' in result
+    assert '<span class="pd-t"></span>' not in result
+
+
+def test_tooltip_css_class(styler):
+    # GH 21266
+    result = styler.set_tooltips(
+        DataFrame([["tooltip"]], index=["x"], columns=["A"]),
+        css_class="other-class",
+        props=[("color", "green")],
+    ).render()
+    assert "#T__ .other-class {\n  color: green;\n" in result
+    assert '#T__ #T__row0_col0 .other-class::after {\n  content: "tooltip";\n' in result
+
+    # GH 39563
+    result = styler.set_tooltips(  # set_tooltips overwrites previous
+        DataFrame([["tooltip"]], index=["x"], columns=["A"]),
+        css_class="another-class",
+        props="color:green;color:red;",
+    ).render()
+    assert "#T__ .another-class {\n  color: green;\n  color: red;\n}" in result