diff --git a/pandas/core/computation/expressions.py b/pandas/core/computation/expressions.py
index 0dbe5e8d83741..ae1928b8535f9 100644
--- a/pandas/core/computation/expressions.py
+++ b/pandas/core/computation/expressions.py
@@ -19,8 +19,6 @@
 
 from pandas._typing import FuncType
 
-from pandas.core.dtypes.generic import ABCDataFrame
-
 from pandas.core.computation.check import NUMEXPR_INSTALLED
 from pandas.core.ops import roperator
 
@@ -83,14 +81,8 @@ def _can_use_numexpr(op, op_str, a, b, dtype_check):
             # check for dtype compatibility
             dtypes: Set[str] = set()
             for o in [a, b]:
-                # Series implements dtypes, check for dimension count as well
-                if hasattr(o, "dtypes") and o.ndim > 1:
-                    s = o.dtypes.value_counts()
-                    if len(s) > 1:
-                        return False
-                    dtypes |= set(s.index.astype(str))
                 # ndarray and Series Case
-                elif hasattr(o, "dtype"):
+                if hasattr(o, "dtype"):
                     dtypes |= {o.dtype.name}
 
             # allowed are a superset
@@ -190,8 +182,6 @@ def _where_numexpr(cond, a, b):
 
 
 def _has_bool_dtype(x):
-    if isinstance(x, ABCDataFrame):
-        return "bool" in x.dtypes
     try:
         return x.dtype == bool
     except AttributeError:
diff --git a/pandas/tests/test_expressions.py b/pandas/tests/test_expressions.py
index 30f88ba5e76f6..43b119e7e1087 100644
--- a/pandas/tests/test_expressions.py
+++ b/pandas/tests/test_expressions.py
@@ -12,7 +12,7 @@
 )
 from pandas.core.computation import expressions as expr
 
-_frame = DataFrame(np.random.randn(10000, 4), columns=list("ABCD"), dtype="float64")
+_frame = DataFrame(np.random.randn(10001, 4), columns=list("ABCD"), dtype="float64")
 _frame2 = DataFrame(np.random.randn(100, 4), columns=list("ABCD"), dtype="float64")
 _mixed = DataFrame(
     {
@@ -36,6 +36,11 @@
 _integer2 = DataFrame(
     np.random.randint(1, 100, size=(101, 4)), columns=list("ABCD"), dtype="int64"
 )
+_array = _frame["A"].values.copy()
+_array2 = _frame2["A"].values.copy()
+
+_array_mixed = _mixed["D"].values.copy()
+_array_mixed2 = _mixed2["D"].values.copy()
 
 
 @pytest.mark.skipif(not expr.USE_NUMEXPR, reason="not using numexpr")
@@ -43,7 +48,9 @@ class TestExpressions:
     def setup_method(self, method):
 
         self.frame = _frame.copy()
+        self.array = _array.copy()
         self.frame2 = _frame2.copy()
+        self.array2 = _array2.copy()
         self.mixed = _mixed.copy()
         self.mixed2 = _mixed2.copy()
         self._MIN_ELEMENTS = expr._MIN_ELEMENTS
@@ -134,25 +141,19 @@ def test_invalid(self):
 
         # no op
         result = expr._can_use_numexpr(
-            operator.add, None, self.frame, self.frame, "evaluate"
-        )
-        assert not result
-
-        # mixed
-        result = expr._can_use_numexpr(
-            operator.add, "+", self.mixed, self.frame, "evaluate"
+            operator.add, None, self.array, self.array, "evaluate"
         )
         assert not result
 
         # min elements
         result = expr._can_use_numexpr(
-            operator.add, "+", self.frame2, self.frame2, "evaluate"
+            operator.add, "+", self.array2, self.array2, "evaluate"
         )
         assert not result
 
         # ok, we only check on first part of expression
         result = expr._can_use_numexpr(
-            operator.add, "+", self.frame, self.frame2, "evaluate"
+            operator.add, "+", self.array, self.array2, "evaluate"
         )
         assert result
 
@@ -160,7 +161,9 @@ def test_invalid(self):
         "opname,op_str",
         [("add", "+"), ("sub", "-"), ("mul", "*"), ("truediv", "/"), ("pow", "**")],
     )
-    @pytest.mark.parametrize("left,right", [(_frame, _frame2), (_mixed, _mixed2)])
+    @pytest.mark.parametrize(
+        "left,right", [(_array, _array2), (_array_mixed, _array_mixed2)]
+    )
     def test_binary_ops(self, opname, op_str, left, right):
         def testit():
 
@@ -170,16 +173,9 @@ def testit():
 
             op = getattr(operator, opname)
 
-            result = expr._can_use_numexpr(op, op_str, left, left, "evaluate")
-            assert result != left._is_mixed_type
-
             result = expr.evaluate(op, left, left, use_numexpr=True)
             expected = expr.evaluate(op, left, left, use_numexpr=False)
-
-            if isinstance(result, DataFrame):
-                tm.assert_frame_equal(result, expected)
-            else:
-                tm.assert_numpy_array_equal(result, expected.values)
+            tm.assert_numpy_array_equal(result, expected)
 
             result = expr._can_use_numexpr(op, op_str, right, right, "evaluate")
             assert not result
@@ -203,7 +199,9 @@ def testit():
             ("ne", "!="),
         ],
     )
-    @pytest.mark.parametrize("left,right", [(_frame, _frame2), (_mixed, _mixed2)])
+    @pytest.mark.parametrize(
+        "left,right", [(_array, _array2), (_array_mixed, _array_mixed2)]
+    )
     def test_comparison_ops(self, opname, op_str, left, right):
         def testit():
             f12 = left + 1
@@ -211,15 +209,9 @@ def testit():
 
             op = getattr(operator, opname)
 
-            result = expr._can_use_numexpr(op, op_str, left, f12, "evaluate")
-            assert result != left._is_mixed_type
-
             result = expr.evaluate(op, left, f12, use_numexpr=True)
             expected = expr.evaluate(op, left, f12, use_numexpr=False)
-            if isinstance(result, DataFrame):
-                tm.assert_frame_equal(result, expected)
-            else:
-                tm.assert_numpy_array_equal(result, expected.values)
+            tm.assert_numpy_array_equal(result, expected)
 
             result = expr._can_use_numexpr(op, op_str, right, f22, "evaluate")
             assert not result