diff --git a/pandas/core/indexing.py b/pandas/core/indexing.py
index a1b06f3c9d6a1..ac0955c6c3e4c 100644
--- a/pandas/core/indexing.py
+++ b/pandas/core/indexing.py
@@ -1865,7 +1865,6 @@ def _setitem_single_block(self, indexer, value, name: str):
         self.obj._check_is_chained_assignment_possible()
 
         # actually do the set
-        self.obj._consolidate_inplace()
         self.obj._mgr = self.obj._mgr.setitem(indexer=indexer, value=value)
         self.obj._maybe_update_cacher(clear=True)