diff --git a/pandas/core/frame.py b/pandas/core/frame.py
index 23c61773daf5a..84ab4fd5c60a1 100644
--- a/pandas/core/frame.py
+++ b/pandas/core/frame.py
@@ -5537,14 +5537,38 @@ def notna(self) -> DataFrame:
     def notnull(self) -> DataFrame:
         return ~self.isna()
 
+    @overload
+    # https://github.com/python/mypy/issues/6580
+    # Overloaded function signatures 1 and 2 overlap with incompatible return types
+    def dropna(  # type: ignore[misc]
+        self,
+        axis: Axis = ...,
+        how: str = ...,
+        thresh: Optional[int] = ...,
+        subset: Optional[Union[Hashable, Sequence[Hashable]]] = ...,
+        inplace: Literal[False] = ...,
+    ) -> DataFrame:
+        ...
+
+    @overload
+    def dropna(
+        self,
+        axis: Axis = ...,
+        how: str = ...,
+        thresh: Optional[int] = ...,
+        subset: Optional[Union[Hashable, Sequence[Hashable]]] = ...,
+        inplace: Literal[True] = ...,
+    ) -> None:
+        ...
+
     def dropna(
         self,
         axis: Axis = 0,
         how: str = "any",
-        thresh=None,
-        subset=None,
+        thresh: Optional[int] = None,
+        subset: Optional[Union[Hashable, Sequence[Hashable]]] = None,
         inplace: bool = False,
-    ):
+    ) -> Optional[DataFrame]:
         """
         Remove missing values.
 
@@ -5683,6 +5707,7 @@ def dropna(
 
         if inplace:
             self._update_inplace(result)
+            return None
         else:
             return result