diff --git a/doc/source/whatsnew/v1.2.0.rst b/doc/source/whatsnew/v1.2.0.rst
index 94eb9a0b3fc58..30a919b9c050b 100644
--- a/doc/source/whatsnew/v1.2.0.rst
+++ b/doc/source/whatsnew/v1.2.0.rst
@@ -678,6 +678,8 @@ Indexing
 - Bug in :meth:`DataFrame.loc` and :meth:`DataFrame.__getitem__`  raising ``KeyError`` when columns were :class:`MultiIndex` with only one level (:issue:`29749`)
 - Bug in :meth:`Series.__getitem__` and :meth:`DataFrame.__getitem__` raising blank ``KeyError`` without missing keys for :class:`IntervalIndex` (:issue:`27365`)
 - Bug in setting a new label on a :class:`DataFrame` or :class:`Series` with a :class:`CategoricalIndex` incorrectly raising ``TypeError`` when the new label is not among the index's categories (:issue:`38098`)
+- Bug in :meth:`Series.loc` and :meth:`Series.iloc` raising ``ValueError`` when inserting a listlike ``np.array``, ``list`` or ``tuple`` in an ``object`` Series of equal length (:issue:`37748`, :issue:`37486`)
+- Bug in :meth:`Series.loc` and :meth:`Series.iloc` setting all the values of an ``object`` Series with those of a listlike ``ExtensionArray`` instead of inserting it (:issue:`38271`)
 
 Missing
 ^^^^^^^
diff --git a/pandas/core/indexers.py b/pandas/core/indexers.py
index b6713bc760c5e..da4654bbf2c10 100644
--- a/pandas/core/indexers.py
+++ b/pandas/core/indexers.py
@@ -79,6 +79,9 @@ def is_scalar_indexer(indexer, ndim: int) -> bool:
     -------
     bool
     """
+    if ndim == 1 and is_integer(indexer):
+        # GH37748: allow indexer to be an integer for Series
+        return True
     if isinstance(indexer, tuple):
         if len(indexer) == ndim:
             return all(
diff --git a/pandas/tests/indexing/test_indexers.py b/pandas/tests/indexing/test_indexers.py
index 744f9441e7376..14b2b494d65fb 100644
--- a/pandas/tests/indexing/test_indexers.py
+++ b/pandas/tests/indexing/test_indexers.py
@@ -28,6 +28,12 @@ def test_is_scalar_indexer():
 
     assert not is_scalar_indexer(slice(None), 1)
 
+    indexer = 0
+    assert is_scalar_indexer(indexer, 1)
+
+    indexer = (0,)
+    assert is_scalar_indexer(indexer, 1)
+
 
 class TestValidateIndices:
     def test_validate_indices_ok(self):
diff --git a/pandas/tests/indexing/test_loc.py b/pandas/tests/indexing/test_loc.py
index f6aa2371cf13a..68f12a939e061 100644
--- a/pandas/tests/indexing/test_loc.py
+++ b/pandas/tests/indexing/test_loc.py
@@ -2072,3 +2072,21 @@ def test_loc_setitem_dt64tz_values(self):
         s2["a"] = expected
         result = s2["a"]
         assert result == expected
+
+    @pytest.mark.parametrize("array_fn", [np.array, pd.array, list, tuple])
+    @pytest.mark.parametrize("size", [0, 4, 5, 6])
+    def test_loc_iloc_setitem_with_listlike(self, size, array_fn):
+        # GH37748
+        # testing insertion, in a Series of size N (here 5), of a listlike object
+        # of size  0, N-1, N, N+1
+
+        arr = array_fn([0] * size)
+        expected = Series([arr, 0, 0, 0, 0], index=list("abcde"), dtype=object)
+
+        ser = Series(0, index=list("abcde"), dtype=object)
+        ser.loc["a"] = arr
+        tm.assert_series_equal(ser, expected)
+
+        ser = Series(0, index=list("abcde"), dtype=object)
+        ser.iloc[0] = arr
+        tm.assert_series_equal(ser, expected)